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Comparative Clinical Pathology

, Volume 28, Issue 4, pp 963–969 | Cite as

Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases

  • Samaneh Goorani
  • Mohsen Zhaleh
  • Majid Hajialiani
  • Rohallah Moradi
  • Mohammad Kazem Koohi
  • Khodabakhsh Rashidi
  • Mohammad Mahdi ZangenehEmail author
  • Akram Zangeneh
Original Article
  • 42 Downloads

Abstract

In recent years, Iranian traditional medicine has been used to control, prevent, and treat various diseases such as fatty liver. One of these plants is Allium eriophyllum Boiss. In this research, we assessed the potential of aqueous extract of A. eriophyllum in the treatment of fatty liver disease in Wistar male rats. At beginning of the study, a total of 10 rats were selected as the negative control, and 50 rats were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into six subgroups, including negative healthy control, untreated negative control, and four groups receiving the aqueous extract of A. eriophyllum at 25, 50, 100, and 200 mg/kg concentrations. After 2 months, the rats were sacrificed, and blood and liver samples were collected. The data were analyzed by SPSS 21 software. All groups of A. eriophyllum (especially A200) could significantly (p ≤ 0.05) decrease the raised weights of body and liver and the concentrations of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, glucose, and GR and increase the concentrations of HDL, total protein, albumin, SOD, CAT, and GPx as compared to the untreated group. Also, A. eriophyllum (especially A200) decreased the degree of hepatic steatosis as compared to the untreated group. In finally, it appears that the aqueous extract of A. eriophyllum can treat the fatty liver disease in rats.

Keywords

Aqueous extract Allium eriophyllum Boiss Fatty liver disease 

Notes

Compliance with ethical standards

Conflict of interest

The authors claim that there is no conflict of interest.

Ethic approval

All institutional and national guidelines for the care and use of laboratory animals were followed.

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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Samaneh Goorani
    • 1
  • Mohsen Zhaleh
    • 2
  • Majid Hajialiani
    • 3
    • 4
  • Rohallah Moradi
    • 4
  • Mohammad Kazem Koohi
    • 1
  • Khodabakhsh Rashidi
    • 5
  • Mohammad Mahdi Zangeneh
    • 4
    • 6
    Email author
  • Akram Zangeneh
    • 4
    • 6
  1. 1.Department of Toxicology, Faculty of Veterinary MedicineUniversity of TehranTehranIran
  2. 2.Department of Medical Laboratory Sciences, School of ParamedicineKermanshah University of Medical SciencesKermanshahIran
  3. 3.Depatment of Organic Chemistry, Faculty of ChemistryBu-Ali Sina UniversityHamedanIran
  4. 4.Biotechnology and Medicinal Plants Research CenterIlam University of Medical SciencesIlamIran
  5. 5.Department of Histology, Faculty of Veterinary MedicineShahid Chamran University of AhvazAhvazIran
  6. 6.Department of Clinical Science, Faculty of Veterinary MedicineRazi UniversityKermanshahIran

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