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Comparative Clinical Pathology

, Volume 28, Issue 1, pp 183–188 | Cite as

Expression of interleukin-15 in canine mammary carcinoma: relationships with histologic grades, Bcl-2, recurrence, and overall survival

  • Massoud Rezaee Oghazi
  • Mohsen MalekiEmail author
  • Ahmad Reza Movassaghi
  • Zahra Kamyabi-Moghaddam
Original Article

Abstract

Spontaneous tumors arising from mammary tissue are considered the most common tumor in female dogs and are of great importance both in veterinary and comparative medicine. Interleukin-15 is a cytokine involved in many physiologic processes such as activation of immune cells, autoimmune diseases, and cancer pathogenesis; however, the role of interleukin-15 in canine mammary cancers has not been well understood. We designed this study to examine the expression of interleukin-15 (IL-15) in canine mammary carcinoma by means of immunohistochemistry and any possible association with histologic malignancy grades, Bcl-2 expression, tumor recurrence, and overall survival. Results revealed that 14 (46.66%) of tumor samples strongly express IL-15, 7 cases (23.33%) moderately, and 9 cases showed weak immunoreactivity (30%). The expression of interleukin-15 is increased in canine mammary tumors in comparison to healthy tissues (p < 0.05). Additionally, interleukin-15 higher expression is significantly in relationship with high histologic grade (p < 0.05), high Bcl-2 expression (p < 0.05), and shorter overall survival (p < 0.05), but not with tumor recurrence (p > 0.05). Interleukin-15 could have a role mammary carcinogenesis in dogs but more studies are needed to understand its exact roles.

Keywords

Canine Histologic grade Immunohistochemistry Interleukin-15 Mammary carcinoma Survival 

Notes

Funding

This study was funded by Ferdowsi University of Mashhad.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathobiology, Faculty of Veterinary MedicineFerdowsi University of MashhadMashhadIran
  2. 2.Faculty of veterinary medicineUniversity of TehranTehranIran

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