Comparative Clinical Pathology

, Volume 29, Issue 1, pp 43–46 | Cite as

Hemodynamic premises of endothelial dysfunction in young patients with vertebrobasilar insufficiency

  • Nataliya Oleksandrivna NekrasovaEmail author
  • Tatiyana Viktorivna Gorbach
  • Iryna Anatolievna Grygorova
  • Olena Leonidivna Tovazhnyanska
Original Article


According to current interpretations, tonal regulation of major arteries is determined by the degree of endothelial function. Shear stress influence on the vascular endothelium is an important part of vascular physiology. The aim of this study was to evaluate endothelial dysfunction, dependent up on the stage of spondylogenic vertebrobasilar insufficiency using the indicator ISD (systole-diastolic index) in young patients with degenerative-dystrophic lesions of cervical spine. Our results show that there is significant association between the status of the endothelial wall and hemodynamic changes (the growth of the systole-diastolic ratio leads to an increase in vasoconstriction factors in the blood). Raised ET-1 together with increase in ISD in patients with spondylogenic vertebrobasilar insufficiency reflects a hemodynamically dependent link to endothelial dysfunction.


Spondylogenic vertebra-basilar insufficiency Shear stress Endothelial dysfunction 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyKharkiv National Medical UniversityKharkivUkraine
  2. 2.Department of BiochemistryKharkiv National Medical UniversityKharkivUkraine

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