Comparative study of tuning of microfabrication parameters for improving electrochemical performance of platinum and glassy carbon microelectrodes in neural prosthetics
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Neural prosthetics, which are increasingly being considered for the dual functionalities of recording and stimulation, are implanted in a corrosive biochemical environment that requires them to possess superior electrical and electrochemical stability and performance. These probes are required to withstand these operating conditions through billions of cycles of pulses of electrical stimulations and also maintain electrochemical sensitivity for potential applications in voltammetry. In this research, microelectrodes made of two material systems; namely, platinum and glassy carbon, supported on a flexible substrate are fabricated and investigated for correlation between process parameters and the electrochemical efficacy of the neural interfaces, particularly charge storage capacity and corrosion rate. Using scanning electron and atomic force microscopies, the correlation between process parameters, surface morphology and topography in both platinum and glassy carbon were investigated. The results demonstrate that changes in surface topography and the rate of corrosion are correlated to variations in the process parameters. Furthermore, the results indicate a relationship between surface roughness and corrosion rate, in which the increase or decrease of the former corresponds to a similar change in the latter.
This material is based on research work supported by National Science Foundation (NSF) Grant Number EEC-1028725 under the ERC program. The authors also acknowledge the use of equipment at the San Diego State University Electron Microscopy Facility acquired by NSF instrumentation grant DBI-0959908. The authors are grateful for Mr. Atif Mohammed for his assistance and insightful discussions about the AFM.
- Badea GE, Caraban A, Sebesan M et al (2010) Polarisation measurements used for corrosion rates determination. J Sustenabke Energy 1:1–4Google Scholar
- Bucher ES, Wightman RM (2015) Electrochemical analysis of neurotransmitters. Annu Rev Anal Chem 8:239–261. https://doi.org/10.1146/annurev-anchem-071114-040426 CrossRefGoogle Scholar
- Cogan SF (2008) Neural stimulation and recording electrodes. Annu Rev Biomed Eng 10:275–309. https://doi.org/10.1146/annurev.bioeng.10.061807.160518 CrossRefGoogle Scholar
- Green RA, Lovell NH, Wallace GG, Poole-Warren LA (2008) Conducting polymers for neural interfaces: challenges in developing an effective long-term implant. Biomaterials 29:3393–3399. https://doi.org/10.1016/j.biomaterials.2008.04.047 CrossRefGoogle Scholar
- Griessenauer CJ, Chang S-Y, Tye SJ et al (2010) Wireless instantaneous neurotransmitter concentration system: electrochemical monitoring of serotonin using fast-scan cyclic voltammetry—a proof-of-principle study. J Neurosurg 113:656–665. https://doi.org/10.3171/2010.3.JNS091627 CrossRefGoogle Scholar
- Mattox DM (1998) Handbook of physical vapor deposition (PVD) processing. Noyes Publications, Park RidgeGoogle Scholar