A novel numerical modeling paradigm for bio particle tracing in non-inertial microfluidics devices
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In this work, we report on the design and implementation of a new method for the two dimensional (2D) simulation of rigid spherical particles trajectory which are to be separated in a microfluidics device based on their sizes. The advantages of efficient particle trajectory simulation method (EPTSM) include drastically smaller runtimes as compared with other methods as well as the ability to include particle collisions with channel’s walls and its ability to be extended to 3D simulations. Numerically simulated results were verified using a specifically designed and fabricated deterministic lateral displacement microfluidic device test structure. The method has provided realistic results for the study of multi-particles throughout the entire channel.
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