Journal of Gastroenterology

, Volume 54, Issue 5, pp 474–475 | Cite as

Is the grade of ballooned hepatocytes a significant risk factor for rapid progression of hepatic fibrosis in patients with NAFLD?

  • Yoshio SumidaEmail author
  • Masashi Yoneda
  • Takeshi Okanoue
  • for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)
Letter to the Editor


Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.


  1. 1.
    Kakisaka K, Suzuki Y, Fujiwara Y, et al. Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease. J Gastroenterol. 2018;53:1285–91.CrossRefGoogle Scholar
  2. 2.
    Brunt EM, Kleiner DE, Wilson LA, NASH CRN, et al. Improvements in histologic features and diagnosis associated with improvement in fibrosis in NASH: results from the NASH clinical research network treatment Trials. Hepatology. 2019. (in press). Google Scholar
  3. 3.
    Shah AG, Lydecker A, Murray K, Nash Clinical Research Network, et al. Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2009;7:1104–12.CrossRefGoogle Scholar
  4. 4.
    Sumida Y, Yoneda M, Hyogo H, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD), et al. Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population. BMC Gastroenterol. 2012;12:2.CrossRefGoogle Scholar
  5. 5.
    Ishiba H, Sumida Y, Tanaka S, Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD), et al. The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study. J Gastroenterol. 2018;53:1216–24.CrossRefGoogle Scholar
  6. 6.
    Chalasani N, Abdelmalek MF, Loomba R, et al. Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients With NASH. Liver Int. 2019. (in press). Google Scholar
  7. 7.
    Siddiqui MS, Yamada G, Vuppalanchi R, NASH Clinical Research Network, et al. Diagnostic accuracy of non-invasive fibrosis models to detect change in fibrosis stage. Clin Gastroenterol Hepatol. 2019. (in press). Google Scholar
  8. 8.
    Okanoue T, Ebise H, Kai T, et al. A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis. J Gastroenterol. 2018;53:129–39.CrossRefGoogle Scholar

Copyright information

© Japanese Society of Gastroenterology 2019

Authors and Affiliations

  • Yoshio Sumida
    • 1
    Email author
  • Masashi Yoneda
    • 1
  • Takeshi Okanoue
    • 2
  • for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)
  1. 1.Division of Hepatology and Pancreatology, Department of Internal MedicineAichi Medical UniversityNagakuteJapan
  2. 2.Hepatology CenterSaiseikai Suita HospitalSuitaJapan

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