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Journal of Gastroenterology

, Volume 53, Issue 8, pp 916–923 | Cite as

Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan

  • Masayoshi Ono
  • Mototsugu Kato
  • Shuichi Miyamoto
  • Momoko Tsuda
  • Takeshi Mizushima
  • Shouko Ono
  • Manabu Nakagawa
  • Katsuhiro Mabe
  • Soichi Nakagawa
  • Shuichi Muto
  • Yuichi Shimizu
  • Mineo Kudo
  • Shinichi Katsuki
  • Takashi Meguro
  • Naoya Sakamoto
Original Article—Alimentary Tract

Abstract

Background

The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria.

Aims

The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan.

Patients and methods

All patients who were booked for colonoscopy were enrolled from eight institutions in Japan. This study was a prospective observational study in the period from April 2013 to December 2013. Patients filled out FGID questionnaires of Rome III when they were waiting for colonoscopy.

Results

Data for 1200 patients who underwent colonoscopy were analyzed. A total of 547 patients (45.6%) were diagnosed with FBDs. Out of those patients, 9.1% had IBS. According to the Rome III diagnostic criteria, 134 patients (11.2%) had functional bloating (FB), 73 (6.1%) had functional constipation (FC), 40 (3.3%) had functional diarrhea (FD), and 191 (15.9%) had unspecified functional bowel disorder (UFBD). Patients with FBDs had significantly higher rates of almost all symptoms (abdominal pain, hard or lumpy stools, loose or watery stools, and bloating) than those in the controls.

Conclusions

In Japan, the prevalence of FBDs and IBS is high, similar to that in the US. Many patients with FBDs have multiple symptoms.

Keywords

FGIDs IBS Functional bowel disorder (FBD) Rome III criteria 

Abbreviations

CS

Colonoscopy

FAPS

Functional abdominal pain syndrome

FB

Functional bloating

FBDs

Functional bowel disorders

FC

Functional constipation

FD

Functional diarrhea

FGIDs

Functional gastrointestinal disorders

IBD

Inflammatory bowel disease

IBS

Irritable bowel syndrome

UFBD

Unspecified functional bowel disorder

Notes

Acknowledgements

We wish to thank Dr. Uehara and Dr. Hokari for participation this study. Mototsugu Kato has served in speaking and teaching commitments for Eisai Co., Ltd., Daiichi Sankyo Company, Ltd., Takeda Pharmaceutical Co. Ltd., Otsuka Pharmaceutical Co., Ltd. and AstraZeneca and has received scholarship grants from Eisai Co., Ltd., Takeda Pharmaceutical Co. Ltd., Daiichi Sankyo Company, Ltd., AstraZeneca and Astellas Pharma Inc. Sakamoto received a research grant from Daiichi-Sankyo, Gilead Sciences, and MSD, and received lecture fees from Bristol-Myers-Squibb, Gilead Sciences, MSD, Otsuka Pharmaceutical, and AbbVie.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japanese Society of Gastroenterology 2018

Authors and Affiliations

  • Masayoshi Ono
    • 1
  • Mototsugu Kato
    • 2
  • Shuichi Miyamoto
    • 3
  • Momoko Tsuda
    • 3
  • Takeshi Mizushima
    • 3
  • Shouko Ono
    • 4
  • Manabu Nakagawa
    • 4
  • Katsuhiro Mabe
    • 2
  • Soichi Nakagawa
    • 4
  • Shuichi Muto
    • 5
  • Yuichi Shimizu
    • 4
  • Mineo Kudo
    • 6
  • Shinichi Katsuki
    • 7
  • Takashi Meguro
    • 8
  • Naoya Sakamoto
    • 3
  1. 1.Department of GastroenterologyHakodate Municipal HospitalHakodateJapan
  2. 2.Department of GastroenterologyNational Hospital Organization Hakodate HospitalHakodateJapan
  3. 3.Department of GastroenterologyHokkaido University Graduate School of MedicineSapporoJapan
  4. 4.Division of EndoscopyHokkaido University HospitalSapporoJapan
  5. 5.Department of GastroenterologyNational Hospital Organization, Hokkaido Medical CenterSapporoJapan
  6. 6.Department of GastroenterologyTouei HospitalSapporoJapan
  7. 7.Center of GastroenterologyOtaru Ekisaikai HospitalOtaruJapan
  8. 8.Department of GastroenterologyHokkaido Gastroenterology HospitalSapporoJapan

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