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Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate

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Abstract

Background

Bleeding from esophagogastric varices is a serious complication of portal hypertension. The aim of the present study was to determine whether endoscopic sclerotherapy with injection of N-butyl-2-cyanoacrylate combined with variceal ligation was useful for hemostasis of bleeding gastric varices.

Methods

Twenty-seven patients with bleeding gastric varices underwent endoscopic treatment with variceal ligation followed by sclerotherapy with N-butyl-2-cyanoacrylate from November 1995 to November 2000. Patients underwent endoscopic variceal ligation only for the bleeding spot just before sclerotherapy. Injection was continued until varices were engorged. After these therapies, patients were followed for at least for 5 years. Retreatment was applied as necessary.

Results

Among these patients, 11 had active bleeding and 16 had recent bleeding within 24 h with white or red plaques on gastric varices. All varices presented as nodular or tumorous forms. The hemostasis rate at 1 week after treatment with N-butyl-2-cyanoacrylate was 88.9% (24/27). Among the patients achieving hemostasis at 1 week, 33.3% (8/24) experienced recurrent bleeding between 5 and 53 months after the initial treatment. Five patients with rebleeding were treated with N-butyl-2-cyanoacrylate, and the other three patients were treated by other procedures. The final hemostasis rate was 81.5% (22/27). The 5-year survival rate after initial hemostasis was 63.0% (17/27).

Conclusions

This study showed that endoscopic variceal ligation combined with sclerotherapy might become a recommended choice for effective treatment of bleeding gastric varices.

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Authors and Affiliations

  1. Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Nozomi Sugimoto, Kenichiro Watanabe, Ryo Shimoda, Hiroyuki Sakata, Yuichiro Eguchi, Toshihiko Mizuta, Seiji Tsunada, Ryuichi Iwakiri & Kazuma Fujimoto

  2. Department of Internal Medicine, Saga Prefectural Hospital Koseikan, Saga, Japan

    Kenichiro Watanabe, Kazuyo Watanabe & Shinichi Ogata

  3. Department of Radiology, Saga Medical School, Saga, Japan

    Junichi Nojiri, Masanobu Mizuguchi & Sho Kudo

  4. Department of Surgery, Saga Medical School, Saga, Japan

    Kohji Miyazaki

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  1. Nozomi Sugimoto
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Sugimoto, N., Watanabe, K., Watanabe, K. et al. Endoscopic hemostasis for bleeding gastric varices treated by combination of variceal ligation and sclerotherapy with N-butyl-2-cyanoacrylate. J Gastroenterol 42, 528–532 (2007). https://doi.org/10.1007/s00535-007-2041-0

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