Supportive Care in Cancer

, Volume 27, Issue 5, pp 1587–1588 | Cite as

Pegfilgrastim in primary prophylaxis of febrile neutropenia in elderly patients with hematological malignancies—bendamustine and G-CSF support

  • Claudio CerchioneEmail author
  • Amalia De Renzo
  • Davide Nappi
  • Maria Di Perna
  • Roberta Della Pepa
  • Novella Pugliese
  • Lucio Catalano
  • Fabrizio Pane
  • Marco Picardi
Letter to the Editor

Dear editor,

We would like to thank Osamu Imataki and his colleagues [1] for their comments on our recent original article about a real-life experience on the use of pegfilgrastim in primary prophylaxis of febrile neutropenia (FN) for patients with non-Hodgkin lymphoma (NHL) undergoing bendamustine plus rituximab (BR) treatment [2]. Their case report is an example of effectiveness of secondary prophylaxis with G-CSF in a setting of advanced mantle cell lymphoma of an elderly patient (82-year-old) who underwent BR [1]. The authors want to highlight how BR could cause prolonged neutropenia, especially during the following courses of therapy, rather than the initial; therefore, a secondary G-CSF prophylaxis is probably advocated as more properly indicated. There is still lack of data regarding the efficacy of a primary or secondary prophylaxis with G-CSF in BR for patients with NHL. However, our real-life experience suggests that, in a primary prophylactic setting, pegfilgrastim seems to...



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of HematologyIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori – IRCCSMeldolaItaly
  2. 2.Hematology – Department of Clinical Medicine and SurgeryAzienda Ospedaliera Universitaria Federico IINaplesItaly

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