Dental treatment needs in hospitalized cancer patients: a retrospective cohort study
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The objectives of this study were to describe the distribution and the clinicopathological features of the most common causes for dental treatment needs during the hospitalization of cancer patients.
A retrospective cohort study of 2664 hospitalized cancer patients that analyzed the main dental treatment needs and dental procedures performed from January 2010 to December 2017.
A total of 2664 medical patients were included in this study. Non-Hodgkin lymphoma (17.2%) was the most common cancer type, followed by leukemia (14.8%), and oral and oropharyngeal squamous cell carcinoma (10.5%). The most common reasons for patients’ hospitalization were chemotherapy protocols (18.8%), monitoring head and neck surgeries (9.7%), and febrile neutropenia (9.6%). The main motivation for the medical team to request dental evaluation was oral mucositis (22.8%) followed by oral pain or toothache (10.8%) and fungal, viral oral infections or traumatic oral lesions (9.9%). The dental treatment needs most observed were pain due to oral mucositis (17%), dental treatment prior to radiotherapy (RT), chemotherapy (CT) or bisphosphonate therapy (BP) (10.8%), teeth extractions (6.5%), and prophylactic photobiomodulation therapy (6.3%), whereas the most common dental treatments performed were oral hygiene protocols (30.2%), photobiomodulation therapy (prophylactic and curative) (21.7%), and dental treatment prior to cancer treatment initiation (RT, CT, and BP) (9.5%).
This study can be considered original in the oncologic context, providing new information about the most frequent dental treatment needs among a large population of hospitalized cancer patients.
KeywordsMouth neoplasms Oral squamous cell carcinoma Oral mucositis Oral dental care
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The present study was approved by the Ethics Committee of the School of Medicine of the University of Sao Paulo (Protocol no. 2.580.090), Sao Paulo, Brazil.
Control of the Data
The authors have full control of all primary data and agree to allow the journal to review our data if requested.
- 4.Davies AN, Brailsford SR, Beighton D (2006) Oral candidosis in patients with advanced cancer. Oral Oncol 42(7):698–702. https://doi.org/10.1016/j.oraloncology.2005.11.010 CrossRefPubMedGoogle Scholar
- 7.Lee MK, Dodson TB, Nalliah RP, Karimbux NY, Allareddy V (2014) Nine-year trend analysis of hospitalizations attributed to oral and oropharyngeal cancers in the United States. Oral Surg Oral Med Oral Pathol Oral Radiol 118(1):47–67. https://doi.org/10.1016/j.oooo.2013.01.019 CrossRefPubMedGoogle Scholar
- 8.Lee MK, Nalliah RP, Kim MK, Elangovan S, Allareddy V, Kumar-Gajendrareddy P, Allareddy V (2011) Prevalence and impact of complications on outcomes in patients hospitalized for oral and oropharyngeal cancer treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(5):581–591. https://doi.org/10.1016/j.tripleo.2011.06.032 CrossRefPubMedGoogle Scholar
- 11.Numico G, Cristofano A, Mozzicafreddo A, Cursio OE, Franco P, Courthod G, Trogu A, Malossi A, Cucchi M, Sirotovà Z, Alvaro MR, Stella A, Grasso F, Spinazzé S, Silvestris N (2015) Hospital admission of cancer patients: avoidable practice or necessary care? PLoS One 10(3):e0120827. https://doi.org/10.1371/journal.pone.0120827 CrossRefPubMedPubMedCentralGoogle Scholar
- 12.Boers-Doets CB, Epstein JB, Raber-Durlacher JE, Ouwerkerk J, Logan RM, Brakenhoff JA, Lacouture ME, Gelderblom H (2012) Oral adverse events associated with tyrosine kinase and mammalian target of rapamycin inhibitors in renal cell carcinoma: a structured literature review. Oncologist 17(1):135–144. https://doi.org/10.1634/theoncologist.2011-0111 CrossRefPubMedGoogle Scholar
- 14.von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, Initiative STROBE (2014) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg 12(12):1495–1499. https://doi.org/10.1016/j.ijsu.2014.07.013 CrossRefGoogle Scholar
- 16.Stephen BH, Steven RC, Thomas BN (2011) Designing cross-sectional and cohort studies. In: Smith J (ed) Designing clinical research, 4rth edn. Lippincott Williams & Wilkins, Philadelphia, pp 85–96Google Scholar
- 17.de Lacerda Vidal CF, Vidal AK, Monteiro JG Jr, Cavalcanti A, Henriques APC, Oliveira M, Godoy M, Coutinho M, Sobral PD, Vilela CÂ, Gomes B, Leandro MA, Montarroyos U, Ximenes RA, Lacerda HR (2017) Impact of oral hygiene involving toothbrushing versus chlorhexidine in the prevention of ventilator-associated pneumonia: a randomized study. BMC Infect Dis 17(1):112. https://doi.org/10.1186/s12879-017-2188-0 CrossRefPubMedPubMedCentralGoogle Scholar
- 18.Basile D, Di Nardo P, Corvaja C, Garattini SK, Pelizzari G, Lisanti C, Bortot L, Da Ros L, Bartoletti M, Borghi M, Gerratana L, Lombardi D, Puglisi F (2019) Mucosal injury during anti-cancer treatment: from pathobiology to bedside. Cancers (Basel) 11(6):857. https://doi.org/10.3390/cancers11060857 CrossRefGoogle Scholar
- 19.Fernandes LL, Torres SR, Garnica M, de Souza GL, Junior AS, de Vasconcellos ÁC, Cavalcanti W, Maiolino A, de Barros Torres MC (2014) Oral status of patients submitted to autologous hematopoietic stem cell transplantation. Support Care Cancer 22(1):15–21. https://doi.org/10.1007/s00520-013-1940-2 CrossRefPubMedGoogle Scholar
- 21.Zecha JAEM, Raber-Durlacher JE, Laheij AMGA, Westermann AM, Epstein JB, de Lange J, Smeele LE (2019) The impact of the oral cavity in febrile neutropenia and infectious complications in patients treated with myelosuppressive chemotherapy. Support Care Cancer 27(10):3667–3679. https://doi.org/10.1007/s00520-019-04925-8 CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Brandão TB, Morais-Faria K, Ribeiro ACP, Rivera C, Salvajoli JV, Lopes MA, Epstein JB, Arany PR, de Castro G Jr, Migliorati CA, Santos-Silva AR (2018) Locally advanced oral squamous cell carcinoma patients treated with photobiomodulation for prevention of oral mucositis: retrospective outcomes and safety analyses. Support Care Cancer 26(7):2417–2423. https://doi.org/10.1007/s00520-018-4046-z CrossRefPubMedGoogle Scholar
- 24.Brandão TB, Vechiato Filho AJ, Batista VE, de Oliveira MC (2016) Santos-Silva AR (2016) Obturator prostheses versus free tissue transfers: a systematic review of the optimal approach to improving the quality of life for patients with maxillary defects. J Prosthet Dent 115(2):247–253CrossRefGoogle Scholar