Self-reported and objective taste and smell evaluation in treatment-naive solid tumour patients
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Taste and smell abnormalities (TSA) commonly occur in cancer and are associated with anorexia, early satiety, malnutrition, weight loss and reduced quality of life. A recent study found a high TSA prevalence in newly diagnosed cancer patients before treatment. This suggests that TSA may originate from the tumour itself. No previous study has examined TSA, both subjectively and objectively, in newly diagnosed, treatment-naïve cancer patients. This study aimed to address this gap.
This prospective observational study recruited consecutive, newly diagnosed, treatment-naïve patients with solid tumours at Radiation Oncology Out-patients. Self-reported taste and smell changes since becoming ill were evaluated using modified Taste and Smell Survey, and objective taste and smell tests were conducted using ‘Sniffin’ Sticks Olfactory Test® and Burghart Taste Strips®. Nutritional status was assessed with abridged Patient-Generated Subjective Global Assessment.
Thirty completed the study. Seventy-four per cent had at least one TSA. Taste changes and/or abnormalities were more prevalent than smell, and subjective taste changes more common than objective abnormalities. Although less common, smell abnormalities impacted quality of life more. TSA characteristics were heterogeneous. Forty-seven per cent were at malnutrition risk. No association was found between TSA and nutritional status.
Over two thirds had at least one TSA and almost half were at malnutrition risk. Self-reported TSA included changes in taste and smell perception, and most commonly persistent bad taste. This study demonstrated the complexity of TSA assessment and the prevalence, severity and impact of these and related symptoms in treatment-naïve cancer patients.
KeywordsCancer Nutrition Taste Smell Symptoms
We would like to acknowledge the nursing and administration staff at the Radiation Oncology Out-patient at St James Hospital for their assistance with data collection processes.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study has not been previously published.
We have full control of all primary data and can allow the journal to review the data if requested.
- 1.Hummel T, Landis BN, Hüttenbrink KB (2011) Smell and taste disorders. GMS Curr Top Otorhinolaryngol Head Neck Surg 10:1–15Google Scholar
- 6.Yoshinaka M, Ikebe K, Uota M, Ogawa T, Okada T, Inomata C, Takeshita H, Mihara Y, Gondo Y, Masui Y, Kamide K, Arai Y, Takahashi R, Maeda Y (2016) Age and sex differences in the taste sensitivity of young adult, young-old and old-old Japanese. Geriatr Gerontol Int 16(12):1281–1288CrossRefGoogle Scholar
- 23.Spotten L, Corish C, Lorton C et al (2016) Subjective taste and smell changes in treatment-naïve people with solid tumours. Support Cancer Care 24:3201–3208Google Scholar
- 30.Leyrer CM, Chan MD, Peiffer AM, Horne E, Harmon M, Carter AF, Hinson WH, Mirlohi S, Duncan SE, Dietrich AM, Lesser GJ (2014) Taste and smell disturbances after brain irradiation: a dose-volume histogram analysis of a prospective observational study. Pract Radiat Oncol 4(2):130–135CrossRefGoogle Scholar
- 31.Gabrielson DK, Scaffidi D, Leung E, Stoyanoff L, Robinson J, Nisenbaum R, Brezden-Masley C, Darling PB (2013) Use of an abridged scored patient-generated subjective global assessment (abPG-SGA) as a nutritional screening tool for cancer patients in an outpatient setting. Nutr and Cancer 65(2):234–239CrossRefGoogle Scholar
- 32.World Health Organisation: BMI Classification. (Internet: http://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi - accessed 31 October 2017)
- 34.Kobal G, Hummel TH, Sekinger B et al (1996) Sniffin’sticks’: screening of olfactory performance. Rhinology 34:222–226Google Scholar
- 36.Gerkin RC, Castro JB (2015) The number of olfactory stimuli that humans can discriminate is still unknown. eLife 4 https://elifesciences.org/articles/08127