Supportive Care in Cancer

, Volume 27, Issue 11, pp 4035–4036 | Cite as

Polyphenols, Mediterranean diet, and colon cancer

  • Anna Vittoria MattioliEmail author
  • Alberto Farinetti
  • Roberta Gelmini
Letter to the Editor

Dear Editor,

We have read with great interest the manuscript “Risk factors affecting hospital stay among patients undergoing colon cancer surgery: a prospective cohort study.” by Orive M and coworkers [1] and we found it very important with a view to clinical prevention. The article aimed to identify and validate risk factors that contribute to prolonged length of hospital stay (LOS) in a prospective cohort study that included 1955 patients undergoing resection for colorectal cancer. They found that some of the strongest independent predictors of prolonged LOS, such as surgical infections or open surgery, could be modified to reduce LOS and, in turn, other adverse outcomes.

With reference to the findings reported in the paper, we would like to make the following contribution to the discussion. Lifestyle and nutrition strongly influence the development and outcome of colon cancer [2].

In a recent paper, we analyzed 3 components of the Mediterranean diet that seems to be associated with...


Authors’ contributions

A.V.M. and A.F. contributed to the study’s concept. A.V.M., A.F., and R.G. contributed to writing the article; all authors contributed to the critical review of the article.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Orive M, Aguirre U, Gonzalez N, Lázaro S, Redondo M, Bare M, Anula R, Briones E, Escobar A, Sarasqueta C, Garcia-Gutierrez S, Quintana JM; REDISSEC-CARESS/CCR group (2019). Risk factors affecting hospital stay among patients undergoing colon cancer surgery: a prospective cohort study. Support Care Cancer 22.
  2. 2.
    Grosso G, Bella F, Godos J, Sciacca S, Del Rio D, Ray S, Galvano F, Giovannucci E (2017) Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors and cancer risk. Nutr Rev 75(6):405–419. CrossRefPubMedGoogle Scholar
  3. 3.
    Farinetti A, Zurlo V, Manenti A, Coppi F, Mattioli AV (2017) Mediterranean diet and colorectal cancer: a systematic review. Nutrition 43-44:83–88CrossRefGoogle Scholar
  4. 4.
    Gill CI, Boyd A, McDermott E, McCann M, Servili M, Selvaggini R et al (2005) Potential anticancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro. Int J Cancer 117:1–7CrossRefGoogle Scholar
  5. 5.
    Wiseman M (2008) The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc 67:253–256CrossRefGoogle Scholar
  6. 6.
    Mattioli AV, Coppi F, Migaldi M, Scicchitano P, Ciccone MM, Farinetti A (2017) Relationship between Mediterranean diet and asymptomatic peripheral arterial disease in a population of pre-menopausal women. Nutr Metab Cardiovasc Dis 27(11):985–990. CrossRefPubMedGoogle Scholar
  7. 7.
    Mattioli AV, Bonetti L, Zennaro M, Bertoncelli P, Mattioli G (2005) Acute myocardial infarction in young patients: nutritional status and biochemical factors. Int J Cardiol 101(2):185–190CrossRefGoogle Scholar
  8. 8.
    Mattioli AV, Bonatti S, Melotti R, Mattioli G (2008) Atrial stunning, inflammation and nutritional status after cardioversion from atrial fibrillation. Int J Cardiol 129:344–347CrossRefGoogle Scholar
  9. 9.
    Carter LG, D’Orazio JA, Pearson KJ (2014) Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer 21:R209–R225CrossRefGoogle Scholar
  10. 10.
    Mattioli AV, Migaldi M, Farinetti A (2018) Coffee in hypertensive women with asymptomatic peripheral arterial disease: a potential nutraceutical effect. J Cardiovasc Med (Hagerstown) 19(4):183–185. CrossRefGoogle Scholar
  11. 11.
    Cotter SC, Reavey CE, Tummala Y, Randall JL, Holdbrook R, Ponton F, Simpson SJ, Smith JA, Wilson K.(2019) Diet modulates the relationship between immune gene expression and functional immune responses. Insect Biochem Mol Biol. CrossRefGoogle Scholar
  12. 12.
    Zhu F, Du B, Xu B (2018) Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: a review. Crit Rev Food Sci Nutr 58(8):1260–1270. CrossRefPubMedGoogle Scholar
  13. 13.
    Mattioli AV, Coppi F, Migaldi M, Farinetti A (2018) Fruit and vegetables in hypertensive women with asymptomatic peripheral arterial disease. J Clinical Nutrition ESPEN 27:110–112CrossRefGoogle Scholar
  14. 14.
    Ringel JB, Jannat-Khah D, Chambers R, Russo E, Merriman L, Gupta R (2019) Impact of gaps in care for malnourished patients on length of stay and hospital readmission. BMC Health Serv Res 19(1):87. CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Somanchi M, Tao X, Mullin GE (2011) The facilitated early enteral and dietary management effectiveness trial in hospitalized patients with malnutrition. J Parenter Enter Nutr 35:209–216. Available from:. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Surgical, Medical and Dental, Morphological Sciences related to Transplant, Oncology and Regenerative MedicineUniversity of Modena and Reggio EmiliaModenaItaly

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