Factors influencing magnesium infusions in hematopoietic cell transplants
To the Editor:
We read with interest the comparison of intravenous (IV) short (mean 2.07 g/h; actual 0.8–6 g/h) vs. prolonged (0.5 g/h) magnesium sulfate infusions in hospitalized autologous and allogeneic hematopoietic cell transplant (HCT) patients . These different rates of magnesium infusion showed no significant improvement in the percentage of days in the therapeutic serum magnesium range of 2–2.7 mg/dL. This was also similarly seen in an outpatient allogeneic HCT population comparing 4 g/h vs. 4 g/2 h with lower magnesium doses (median 2.2 vs. 2.9 g/day, respectively) needed over the shorter infusion duration of 1 h .
The short magnesium infusion group had a mean hospital length of stay of 24.4 days with 6.2 days of magnesium repletion totaling 21.4 g received compared to the prolonged magnesium infusion group staying 29 days in the hospital with 7.2 days of magnesium repletion totaling 22.5 g received. The magnesium dosing and treatment threshold for hypomagnesemia was...
Authors had access to the data and participated in writing the manuscript.
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Conflict of interest
The authors declare that they have no conflicts of interest.