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Incidence and severity of sexual dysfunction among women with breast cancer: a meta-analysis based on female sexual function index

  • Liwei Jing
  • Chao Zhang
  • Wei Li
  • Feng Jin
  • Aiping WangEmail author
Review Article

Abstract

Purpose

Previous meta-analyses have examined the prevalence of sexual dysfunction among women with cancer, but there is no breast cancer (BC)-specific study. We therefore conducted a meta-analysis to examine the prevalence and severity of female sexual dysfunction (FSD) in women with BC.

Methods

We searched PubMed, Embase, Cochrane Library, CNKI, WanFang Data, and VIP for relevant studies published between April 2000 and January 2017. Data were extracted from studies which assessed FSD prevalence and sexual function in women with BC using the female sexual function index (FSFI). Meta-analyses were performed by pooling the prevalence rates of FSD and total FSFI scores. Meta regression was performed to explore the sources of heterogeneity.

Results

We selected 19 published studies involving a total of 2684 women with BC. In this study population, overall FSD prevalence was 73.4% (95% confidence interval (CI) 64.0%, 82.8%), and the total FSFI score was 19.28 (95% CI 17.39, 21.16). Among Asian, American, and European women with BC, there were significant differences in FSD prevalence (P < 0.001), and there was marginally significant difference (P = 0.07) in sexual function between these groups. There was also a marginally significant difference between individuals from mainland China and from other countries in FSD prevalence (P = 0.06) and FSFI score (P = 0.07).

Conclusions

Overall, women with BC have high FSD prevalence and low sexual function. American women with BC have a higher average FSD prevalence and lower average sexual function than Asian women with BC. The FSD prevalence in women with BC in mainland China was slightly higher than in other countries.

Keywords

Breast cancer Female sexual function index Female sexual dysfunction Prevalence Meta-analysis 

Notes

Acknowledgements

We thank Guangxiao Li, Department of Clinical Epidemiology and Evidence-based Medicine of China Medical University, for his kindly help.

Funding information

This study was supported by National Natural Science Foundation of China (No. 81803106), Ph.D. Foundation of North China University of Science and Technology (No. BS2017057).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Human and animal rights

This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Liwei Jing
    • 1
    • 2
  • Chao Zhang
    • 3
  • Wei Li
    • 4
  • Feng Jin
    • 5
  • Aiping Wang
    • 6
    Email author
  1. 1.National Academy of Development and StrategyRenmin University of ChinaBeijingChina
  2. 2.College of Nursing and RehabilitationNorth China University of Science and TechnologyTangshanChina
  3. 3.Affiliated Hospital of North China University of Science and TechnologyTangshanChina
  4. 4.Radiotherapy DepartmentTangshan People’s HospitalTangshanChina
  5. 5.Breast SurgeryFirst Affiliated Hospital of China Medical UniversityShenyangChina
  6. 6.Department of NursingFirst Affiliated Hospital of China Medical UniversityShenyangChina

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