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Effect of gastrectomy on blood pressure in early gastric cancer survivors with hypertension

  • Hak Jin Kim
  • Eun Jeong Cho
  • Mi Hyang Kwak
  • Bang Wool Eom
  • Hong Man Yoon
  • Soo-Jeong Cho
  • Jong Yeul Lee
  • Chan Gyoo Kim
  • Keun Won Ryu
  • Young-Woo Kim
  • Il Ju Choi
Original Article

Abstract

Purpose

We investigated the effect of gastrectomy on blood pressure (BP) in early gastric cancer survivors with hypertension and whether well-controlled BP was due solely to surgery-induced weight loss.

Methods

The study enrolled 66 early gastric cancer patients with hypertension, undergoing endoscopic submucosal dissection (ESD), or gastrectomy. Blood analyses, 24-h ambulatory BP monitoring, brachial ankle pulse wave velocity (baPWV), and echocardiography were measured prior to, 3 months after, and 1 year after ESD or gastrectomy. The primary endpoint was remission of hypertension at 1 year.

Results

The remission rate of hypertension was significantly higher in the gastrectomy group than in the ESD group (p = 0.006). Those with remission of hypertension had a significant weight loss (p < 0.001), decrease in body mass index (p < 0.001), 24-h total systolic BP (p = 0.047), baPWV (p = 0.042), triglycerides (p = 0.049) and apolipoprotein B/apolipoprotein A1 (p = 0.004), and an increase in high-density lipoprotein cholesterol (p < 0.001) at 1 year. Upon multivariate logistic regression analysis, gastrectomy [odds ratio (OR) = 7.77, 95% confidence interval (CI) = 2.05–35.89], diuretic use (OR = 3.76, 95% CI = 1.14–13.98), and lower 24-h total diastolic BP before treatment (OR = 0.90, 95% CI = 0.82–0.96) were predictive of remission of hypertension after adjusting for percent weight.

Conclusions

In early gastric cancer survivors with hypertension, gastrectomy resulted in better BP control than did ESD, which may be due to the gastrectomy itself, beyond weight loss. Therefore, it should be remembered that the adequate reduction of antihypertensives may be necessary in early gastric cancer survivors after gastrectomy.

Keywords

Early gastric cancer Gastrectomy Hypertension Weight loss 

Notes

Funding

This work was supported by research grants NCC1210552-3 (PI: Keun Won Ryu) and NCC1510740-1 (PI: Mi Hyang Kwak) from the National Cancer Center, Republic of Korea.

Compliance with ethical standards

The study was approved by the institutional review board of the National Cancer Center (NCCNCS-12-563). All procedures performed were in accordance with the ethical standards of the institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflicts of interest.

Data

The authors have full control of all primary data and agree that the journal may review the data if requested.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hak Jin Kim
    • 1
  • Eun Jeong Cho
    • 1
  • Mi Hyang Kwak
    • 1
  • Bang Wool Eom
    • 2
  • Hong Man Yoon
    • 2
  • Soo-Jeong Cho
    • 2
  • Jong Yeul Lee
    • 2
  • Chan Gyoo Kim
    • 2
  • Keun Won Ryu
    • 2
  • Young-Woo Kim
    • 2
  • Il Ju Choi
    • 2
  1. 1.Department of Cardiology, Center for Clinical SpecialtyNational Cancer CenterGoyang-siRepublic of Korea
  2. 2.Center for Gastric CancerNational Cancer CenterGoyang-siKorea

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