Effects of exercise on the quality of life in breast cancer patients: a systematic review of randomized controlled trials
The purpose of this study was to conduct a systematic review to assess the effect of exercise on the quality of life among people with breast cancer.
We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Cochrane Library, PubMed, EMBASE, Web of Science, CINAHL, and four Chinese databases were searched for studies published until January 2018. The review included all randomized controlled trials that evaluated the effect of exercise on quality of life compared with that of usual care for people with breast cancer. Two reviewers independently assessed the quality of all the included studies using the Cochrane Handbook for Systematic Reviews of Interventions.
In total, 36 studies (3914 participants) met the inclusion criteria. We divided the exercise into three modes: aerobic, resistance, and a combination of aerobic and resistance. All three modes of exercise intervention showed a significant effect on quality of life between groups.
Exercise is a safe and effective method of improving the quality of life in patients with breast cancer. In particular, combined training was associated with a significant improvement in quality of life. In future research, more high-quality, multicenter trials evaluating the effect of exercise in breast cancer patients are needed.
KeywordsBreast cancer Physical activity Quality of life Systematic review
Breast cancer subscale
Body Image and Relationships Scale
- EORTC QLQ-BR23
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast
- EORTC QLQ-C30
European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30
Functional Assessment of Cancer Therapy-Anemia scale
Functional Assessment of Cancer Therapy-Breast questionnaire
Functional Assessment of Cancer Therapy-General
Health-related quality of life
Physical Component Summary
Quality of life
Randomized controlled trials
36-item Short-Form Health Survey
Trial Outcome Index-Anemia
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
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