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Supportive Care in Cancer

, Volume 26, Issue 6, pp 1691–1694 | Cite as

Diagnostic-driven antifungal approach in neutropenic patients at high risk for chronic disseminated candidiasis: preliminary observations on the role of 1,3-β-D-glucan antigenemia and multiphasic contrast-enhanced computed tomography

  • Roberta Della PepaEmail author
  • Claudio Cerchione
  • Novella Pugliese
  • Roberta Colicchio
  • Paola Salvatore
  • Cesare Sirignano
  • Ernesto Soscia
  • Livio Pagano
  • Maurizio Sanguinetti
  • Fabrizio Pane
  • Marco Picardi
Letter to the editor
  • 162 Downloads

Dear Editor,

Chronic disseminated candidiasis (CDC) is a critical form of invasive fungal infection (IFI) that affects mainly the liver, spleen, and, occasionally, kidneys [1]. Typical clinical, microbiological, and/or radiological manifestations have late onset, leading frequently to misdiagnosis [1, 2]. A late diagnosis leads to a delay in starting an effective antifungal therapy against Candida infection resulting in a severe morbidity and high mortality [3]. Recent studies have shown effective alternatives to traditional microbiological and radiological procedures for the diagnosis of CDC, in particular, 1,3-β-D-glucan (BDG) antigenemia and contrast-enhanced computed tomography (CE-CT) [4, 5]. The preemptive approach, based on the routine surveillance with serum BDG and hepatosplenic CE-CT, has been proposed for obtaining a reliable and early diagnosis of CDC, and for establishing a proper antifungal treatment [6]. However, guidelines give moderate evidence to support...

Notes

Compliance with ethical standards

Conflict of interest

The corresponding author has full control of all primary data and agrees to allow the journal to review their data if requested.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Roberta Della Pepa
    • 1
    Email author
  • Claudio Cerchione
    • 1
  • Novella Pugliese
    • 1
  • Roberta Colicchio
    • 2
  • Paola Salvatore
    • 2
    • 3
  • Cesare Sirignano
    • 4
  • Ernesto Soscia
    • 4
  • Livio Pagano
    • 5
  • Maurizio Sanguinetti
    • 6
  • Fabrizio Pane
    • 1
  • Marco Picardi
    • 7
  1. 1.Department of Clinical Medicine and SurgeryFederico II UniversityNaplesItaly
  2. 2.Department of Molecular Medicine and Medical BiotechnologyFederico II UniversityNaplesItaly
  3. 3.CEINGE, Biotecnologie Avanzate s.c.ar.l.NaplesItaly
  4. 4.Istituto di Biostrutture e BioimmaginiConsiglio Nazionale delle RicercheNaplesItaly
  5. 5.Institute of HematologyUniversità Cattolica del Sacro CuoreRomeItaly
  6. 6.Institute of MicrobiologyUniversità Cattolica del Sacro CuoreRomeItaly
  7. 7.Department of Advanced Biomedical ScienceFederico II UniversityNaplesItaly

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