Supportive Care in Cancer

, Volume 26, Issue 6, pp 1833–1840 | Cite as

Sleep disorder diagnoses and clinical outcomes among hospitalized breast cancer patients: a nationwide inpatient sample study

  • Neomi Vin-RavivEmail author
  • T. F. Akinyemiju
  • S. Galea
  • D. H. Bovbjerg
Original Article



Sleep disturbances are recognized as a problem for many cancer patients, but little is known about the prevalence of sleep disorders among women hospitalized with breast cancer, or their relationship to in-hospital outcomes. The present study represents a first step toward determining the clinical significance of sleep disorders for hospitalized breast cancer patients with regard to complications, length of hospital stay, and mortality.


The relationships between sleep disorders and in-hospital outcomes among 84,424 hospitalized breast cancer patients were examined. This study analyzed the Nationwide Inpatient Sample (NIS) database (2007 to 2011) for all women ages 40 years and older with a primary discharge diagnosis of breast cancer and a secondary discharge diagnosis of sleep disorder. Odds ratios, estimates, and 95% confidence intervals were computed using multivariable regression adjusting for age, comorbidities, race, cancer stage, income, insurance type, residential region, year of discharge, and surgical treatment type.


Among women hospitalized with a primary diagnosis of breast cancer, 2% (n = 1807) also received a diagnosis of a sleep disorder during hospitalization, the majority of which were sleep-related breathing disorders (n = 1274). Although there was no significant association between having a diagnosis of a sleep disorder and in-hospital mortality, patients with a sleep disorder were more likely to also experience complications (OR = 1.58, 95% CI 1.29–1.34) and have longer hospital stays (mean = 0.44 days longer, 95% CI 0.25–0.63).


Hospitalized breast cancer patients with a sleep disorder were more likely to experience clinical complications and stay longer in the hospital. It remains an open and important question for future research whether interventions to improve sleep during hospitalization would help to improve clinical outcomes.


Breast cancer Sleep disorders Inpatients Mortality Complications 



The authors thank Ms. Molly M. Hess and Ms. Jessica Manculich for editorial assistance on an earlier draft of the manuscript.

Funding information

Dr. Dana H. Bovbjerg was supported in part by the National Cancer Institute (P30 CA047904).

Compliance with ethical standards

Ethics approval

Since only analyses on de-identified data were performed, the University Birmingham Alabama Institutional Review Board exempted this study from ethical review.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Neomi Vin-Raviv
    • 1
    • 2
    Email author
  • T. F. Akinyemiju
    • 3
  • S. Galea
    • 4
  • D. H. Bovbjerg
    • 5
  1. 1.School of Social Work, College of Health and Human SciencesColorado State UniversityFort CollinsUSA
  2. 2.University of Northern Colorado Cancer Rehabilitation Institute, School of Sport and Exercise ScienceUniversity of Northern ColoradoGreeleyUSA
  3. 3.Department of EpidemiologyUniversity of Alabama School of Public HealthBirminghamUSA
  4. 4.Department of EpidemiologyBoston University School of Public HealthBostonUSA
  5. 5.University of Pittsburgh, and the UPMC-Hillman Cancer CenterDivision Departments of Psychiatry, Psychology, Behavioral & Community Health Sciences, and Health & Community SystemsPittsburghUSA

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