Efficacy of palonosetron to prevent delayed nausea and vomiting in non-Hodgkin’s lymphoma patients undergoing repeated cycles of the CHOP regimen
Few studies have investigated the effect of palonosetron on delayed chemotherapy-induced nausea and vomiting in lymphoma patients receiving the CHOP regimen. We conducted a prospective clinical trial to assess the efficacy of palonosetron in patients receiving the CHOP regimen.
Complete control (CC: emesis-free and mild nausea) during delayed phase (24–120 h) was the primary endpoint. The secondary endpoint was complete response (CR: emesis-free) during acute (0–24 h), delayed, and overall phases (0–120 h), and CC during acute and overall phases. Palonosetron (0.75 mg) was administered before chemotherapy on day 1 of both the first and second CHOP cycles.
The efficacy of palonosetron in preventing emesis was evaluated in 40 patients. Across two cycles, over 85% of patients achieved CR. As the primary endpoint, the proportion of patients achieving CC in the delayed phase increased from 70% (cycle 1) to 85% (cycle 2). CR rate in the delayed phase increased from 85% (cycle 1) to 95% (cycle 2).
These results suggest that the antiemetic effects during the delayed phase were inferior to those in the acute phase during the first cycle. However, even at the same dose of palonosetron, CR and CC rates increased in the second cycle.
KeywordsPalonosetron Non-Hodgkin’s lymphoma Chop
We wish to thank all of the physicians, nurses, pharmacists, and support personnel for care of the patients participating in this study.
Compliances with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
All procedures performed in studies involving human participants were in accordance with the ethical standards in the 1964 Declaration of Helsinki and its later amendments or with comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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