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Supportive Care in Cancer

, Volume 25, Issue 11, pp 3457–3464 | Cite as

Longitudinal perceptions of the side effects of chemotherapy in patients with gynecological cancer

  • Hui-Chun Hsu
  • Su-Yu Tsai
  • Shang-Liang Wu
  • Shiow-Roug Jeang
  • Mei-Yao Ho
  • Wen-Shiung Liou
  • An-Jen ChiangEmail author
  • Tsung-Hsien Chang
Original Article

Abstract

Purpose

This study aimed to assess the incidence and difference of side effects among six courses of chemotherapy (C/T) in gynecological cancer patients.

Methods

The study period was from Sep. 2010 to Dec. 2011 at the Kaohsiung Veterans General Hospital in Taiwan. The treating protocols, courses, and drugs of C/T in patient were considered according to the different malignant cancers and clinical conditions. The patient data of age, marriage status, education, religion, and experiences of C/T were collected. The patients’ or their families’ reported side effects of C/T were recorded daily from the beginning of C/T to the 10th day after C/T in each cycle and every course of C/T.

Results

Total 89 patients enrolled into the study received total 450 courses of C/T. The mean age was 54.52 ± 11.02. Ovarian cancer was the most common malignant disease (64.0%). The most often combination of drugs used was Taxol and carboplatin (40.9%). Patients complained peripheral numbness of limbs, with the highest incidence of 58.6%. The side effects with incidence about 50% were decreased fatigue (55.0%) and hair loss (49.9%). Other side effects with different levels of incidence were also noticed, such as lack of appetite, changes in taste, and muscle ache. The incidences of peripheral limb numbness and hair loss were increased with following courses of C/T. The high incidence of fatigue did not show variation between different courses of C/T.

Conclusion

This study revealed the incidence of side effects and occurrence timing during C/T in patients with gynecological cancer. These data provide substantial information to patients and their families to understand the potential side effects of C/T courses, which might increase their compliance in receiving adjuvant C/T. Relieving the side effects in C/T would be important to improve their quality of daily life and treatment willingness.

Keywords

Gynecological cancer Chemotherapy Side effects Peripheral neuropathy CIPN 

Notes

Acknowledgements

The study was supported by grants from Kaohsiung Veterans General Hospital, Taiwan (VGHKS103-086), and Veterans General Hospital—National Sun Yat-Sen University (VGHNSU103-006), Taiwan.

Compliance with ethical standards

Ethical approval for this study was obtained from the KSVGH Institutional Review Board.

Funding

Hui-Chun Hsu received research funding (VGHKS103-086 and VGHNSU103-006) from Department of Nursing, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Hui-Chun Hsu
    • 1
    • 2
  • Su-Yu Tsai
    • 1
  • Shang-Liang Wu
    • 3
  • Shiow-Roug Jeang
    • 1
  • Mei-Yao Ho
    • 2
  • Wen-Shiung Liou
    • 4
    • 5
    • 6
  • An-Jen Chiang
    • 4
    • 5
    • 6
    • 7
    Email author
  • Tsung-Hsien Chang
    • 8
  1. 1.Department of NursingKaohsiung Veterans General HospitalKaohsiungTaiwan
  2. 2.Health Care and the University of Technology Graduate School of The Meiho UniversityPingtungTaiwan
  3. 3.Environment and Population HealthGriffith UniversityNathanAustralia
  4. 4.Department of Obstetrics and GynecologyKaohsiung Veterans General HospitalKaohsiungRepublic of China
  5. 5.Institute of Biomedical SciencesNational Sun Yat-Sen UniversityKaohsiungTaiwan
  6. 6.Department of Obstetrics and GynecologyNational Defense Medical CenterTaipeiTaiwan
  7. 7.Department of Obstetrics and GynecologyNational Yang-Ming UniversityTaipeiTaiwan
  8. 8.Department of Medical Education and ResearchKaohsiung Veterans General HospitalKaohsiungTaiwan

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