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Supportive Care in Cancer

, Volume 25, Issue 4, pp 1201–1207 | Cite as

Impact of intensity and timing of integrated home palliative cancer care on end-of-life hospitalization in Northern Italy

  • M. Pellizzari
  • D. Hui
  • E. Pinato
  • M. Lisiero
  • S. Serpentini
  • L Gubian
  • F. Figoli
  • M. Cancian
  • C. De Chirico
  • E. FerroniEmail author
  • F. Avossa
  • M. Saugo
Original Article

Abstract

Purpose

The Veneto Region implemented a novel integrated home-based palliative cancer care (HPCC) program embedded in primary care. We examined the impact of timing and intensity of this program on the quality of end-of-life (EOL) care.

Methods

We selected adult cancer patients died in the Veneto Region between March and December 2013, excluding those died from haematological malignancies as well as the very elderly (85+ years). We retrieved the claim-based data on hospitalization and homecare visits, and defined two observation windows: 90 to 16 days before death to examine intensity of HPCC exposure, and the last 15 days of life to examine EOL outcomes, including hospital death, any hospital stay for medical reasons and hospital stay ≥7 days for medical reasons. Multivariate analysis was conducted using a Poisson model.

Results

Among the 2211 adults who died of solid tumours and received 1+ homecare visits during the exposure period, 1077 (48.7%), 552 (25.0%) and 582 (26.3%) had 0.1–1.9, 2–3.9 and 4+ homecare visits/week, respectively. The median duration between an HPCC home visit and death was 92 days (IQR 42–257 days). Hospital death occurred in 856 (38.7%) patients, while 1087 (49.2%) and 556 (25.1%) had a hospital stay and a hospital stay ≥7 days during the exposure period, respectively. In the multivariate analysis, a greater intensity of integrated HPCC (4+ visits/week) was significantly associated with a lower risk of hospital death (relative risk [RR] = 0.67, 0.59–0.76), any hospital stay (RR = 0.69, 0.62–0.77) and hospital stay ≥7 days for medical reasons (RR = 0.59, 0.49–0.71). A late activation (≤30 days before death) of HPCC was also associated with increased both hospital stay (RR = 1.26, 0.11–1.42) and hospital stay ≥7 days (RR = 1.25, 1.01–1.54).

Conclusions

A greater HPCC program intensity reduces the risk of hospital death and hospital stay in the end-of-life. An early activation of this program can contribute to improve these EOL outcomes.

Keywords

Palliative cancer care End-of-life Home visits Hospitalization Place of death 

Notes

Acknowledgments

We are grateful to the Director of the Social and Health Service Department of the Veneto Region Dr. Domenico Mantoan for encouraging and contributing to this research and to all the colleagues carrying out integrated home palliative care throughout the Veneto Region (nurses, GPs, specialists in palliative care, out-of-hours physicians, social workers), as well as to the Director of Primary Health Care Services of the Veneto Region (Dr. Maria Cristina Ghiotto).

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Funding

There is no funding to report for this submission. No author received awarded grants.

Supplementary material

520_2016_3510_MOESM1_ESM.docx (33 kb)
ESM 1 (DOCX 32 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • M. Pellizzari
    • 1
  • D. Hui
    • 2
  • E. Pinato
    • 1
  • M. Lisiero
    • 3
  • S. Serpentini
    • 4
  • L Gubian
    • 5
  • F. Figoli
    • 6
  • M. Cancian
    • 7
  • C. De Chirico
    • 8
  • E. Ferroni
    • 1
    Email author
  • F. Avossa
    • 1
  • M. Saugo
    • 1
  1. 1.Epidemiological Service of the Veneto RegionPaduaItaly
  2. 2.Department of Palliative Care and Rehabilitation MedicineMD Anderson Cancer CenterHoustonUSA
  3. 3.Hospital Direction, Local Health Unit n° 8AsoloItaly
  4. 4.Palliative Care Unit Local Health Unit n° 3Bassano del Grappa and Veneto Oncology InstitutePaduaItaly
  5. 5.Information Technology Service of the Veneto RegionVeneziaItaly
  6. 6.Palliative Care Unit, Local Health Unit n° 4ThieneItaly
  7. 7.GP, Local Health Unit n° 7ConeglianoItaly
  8. 8.Palliative Care Unit, Local Health Unit n° 7Pieve di SoligoItaly

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