Dental health status and patient-reported outcomes at baseline in patients participating in the osteonecrosis of the jaw registry study, SWOG S0702
SWOG S0702 was a cohort study of patients with cancer with bone metastases due to any cancer. Using baseline data from S0702, this report characterizes the oral health and oral health-related quality of life (OHRQoL) of patients with advanced cancer.
S0702 case report forms captured dental assessment and patient-reported outcome (PRO) data. This analysis compares PRO dental discomfort with selected clinical assessments of dental health. This analysis focuses on the 2294 patients who underwent baseline dental examination prior to study registration, but also reports on the 1235 patients for whom only OHRQol data are available. Dental characteristics including the number of teeth and the presence of gingivitis and periodontal disease were examined for correlation with PRO of oral pain, interference with eating, smiling, speech, or quality of life.
The median age of the study participants was 62. Greater than 60% of the 2294 patients with baseline dental assessments had none to mild plaque, calculus, gingivitis, or periodontal disease, suggesting that most of this cohort had good oral hygiene. However, in each of these same categories, approximately 6% had dental findings classified as severe conditions (poor oral hygiene). There was strong evidence that the presence of periodontal disease, gingivitis, and number of teeth was correlated with lower OHRQoL across multiple domains, including pain (mouth or jaw), interference with eating, smiling and speech, and overall quality of life.
This report characterizes the oral health and OHRQoL of patients with advanced bone metastases receiving palliative therapy.
ClinicalTrials.gov Identifier: NCT00874211
KeywordsOral health Cancer Bone metastases Patient-reported outcomes
Danika L. Lew, MD, provided statistical assistance; Lisa Hansen, RN, MS, provided clinical input; and Kimberly Kaberle and Diane Liggett, BS, were responsible for protocol coordination and data management.
No compensation was received beyond their salary for this work.
Compliance with ethical standards
The participating sites obtained institutional review board approval. Informed, written consent was obtained from all patients prior to enrollment.
Conflict of interest
The authors declare that they have no conflicts of interest. SWOG and the authors have full control of the primary data. We agree to allow the journal to review aggregate level data, if requested.
Funding for this work was provided National Institutes of Health, National Cancer Institute, NCI Community Oncology Research Program (NCORP) Research Base grant, 5UG1CA189974.
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