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Supportive Care in Cancer

, Volume 25, Issue 4, pp 1191–1199 | Cite as

Dental health status and patient-reported outcomes at baseline in patients participating in the osteonecrosis of the jaw registry study, SWOG S0702

  • Catherine H. Van PoznakEmail author
  • Amy Darke
  • Carol M. Moinpour
  • Robert A. Bagramian
  • Mark M. Schubert
  • Julie R. Gralow
  • James L. WadeIII
  • Joseph M. Unger
Original Article

Abstract

Purpose

SWOG S0702 was a cohort study of patients with cancer with bone metastases due to any cancer. Using baseline data from S0702, this report characterizes the oral health and oral health-related quality of life (OHRQoL) of patients with advanced cancer.

Methods

S0702 case report forms captured dental assessment and patient-reported outcome (PRO) data. This analysis compares PRO dental discomfort with selected clinical assessments of dental health. This analysis focuses on the 2294 patients who underwent baseline dental examination prior to study registration, but also reports on the 1235 patients for whom only OHRQol data are available. Dental characteristics including the number of teeth and the presence of gingivitis and periodontal disease were examined for correlation with PRO of oral pain, interference with eating, smiling, speech, or quality of life.

Results

The median age of the study participants was 62. Greater than 60% of the 2294 patients with baseline dental assessments had none to mild plaque, calculus, gingivitis, or periodontal disease, suggesting that most of this cohort had good oral hygiene. However, in each of these same categories, approximately 6% had dental findings classified as severe conditions (poor oral hygiene). There was strong evidence that the presence of periodontal disease, gingivitis, and number of teeth was correlated with lower OHRQoL across multiple domains, including pain (mouth or jaw), interference with eating, smiling and speech, and overall quality of life.

Conclusions

This report characterizes the oral health and OHRQoL of patients with advanced bone metastases receiving palliative therapy.

Trial registration

ClinicalTrials.gov Identifier: NCT00874211

Keywords

Oral health Cancer Bone metastases Patient-reported outcomes 

Notes

Acknowledgements

Danika L. Lew, MD, provided statistical assistance; Lisa Hansen, RN, MS, provided clinical input; and Kimberly Kaberle and Diane Liggett, BS, were responsible for protocol coordination and data management.

No compensation was received beyond their salary for this work.

Compliance with ethical standards

The participating sites obtained institutional review board approval. Informed, written consent was obtained from all patients prior to enrollment.

Conflict of interest

The authors declare that they have no conflicts of interest. SWOG and the authors have full control of the primary data. We agree to allow the journal to review aggregate level data, if requested.

Funding

Funding for this work was provided National Institutes of Health, National Cancer Institute, NCI Community Oncology Research Program (NCORP) Research Base grant, 5UG1CA189974.

Supplementary material

520_2016_3509_MOESM1_ESM.pdf (306 kb)
ESM 1 (PDF 305 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Catherine H. Van Poznak
    • 1
    Email author
  • Amy Darke
    • 2
  • Carol M. Moinpour
    • 3
  • Robert A. Bagramian
    • 4
  • Mark M. Schubert
    • 5
  • Julie R. Gralow
    • 6
  • James L. WadeIII
    • 7
  • Joseph M. Unger
    • 2
  1. 1.University of MichiganAnn ArborUSA
  2. 2.SWOG Statistical Center, Fred Hutchinson Cancer CenterSeattleUSA
  3. 3.Fred Hutchinson Cancer CenterUniversity of WashingtonSeattleUSA
  4. 4.School of DentistryUniversity of MichiganAnn ArborUSA
  5. 5.School of DentistryUniversity of WashingtonSeattleUSA
  6. 6.University of WashingtonSeattleUSA
  7. 7.Heartland NCORP/Cancer Care Specialists of Central IllinoisDecaturUSA

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