Prospective associations of cardiovascular disease with physical performance and disability
Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal.
This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample.
This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements.
The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006).
In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
KeywordsCardiovascular disease Chair stand time Gait Speed WOMAC Osteoarthritis
Compliance with ethical guidelines
Conflict of interest
N. Veronese, B. Stubbs, S.E. Jackson, A. Koyanagi, V. Noventa, F. Bolzetta, A. Cester, P. Soysal, S. Maggi, G.F. López-Sánchez, M. Loosemore, J. Demurtas, and L. Smith declare that they have no competing interests.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all individual participants included in the study.
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