New insights into the pathogenesis of Streptococcus pneumoniae–associated hemolytic uremic syndrome

  • Rebecca R. Scobell
  • Bernard S. Kaplan
  • Lawrence CopelovitchEmail author


The purpose of this review is to describe Streptococcus pneumoniae–associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value.


P-HUS Alternative complement pathway Eculizumab Plasmapheresis 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© IPNA 2019

Authors and Affiliations

  1. 1.Division of Nephrology, Department of PediatricsThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA

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