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Innate immunity and urinary tract infection

  • Christina Ching
  • Laura Schwartz
  • John David Spencer
  • Brian BecknellEmail author
Educational Review

Abstract

Urinary tract infections are a severe public health problem. The emergence and spread of antimicrobial resistance among uropathogens threaten to further compromise the quality of life and health of people who develop acute and recurrent upper and lower urinary tract infections. The host defense mechanisms that prevent invasive bacterial infection are not entirely delineated. However, recent evidence suggests that versatile innate immune defenses play a key role in shielding the urinary tract from invading uropathogens. Over the last decade, considerable advances have been made in defining the innate mechanisms that maintain immune homeostasis in the kidney and urinary tract. When these innate defenses are compromised or dysregulated, pathogen susceptibility increases. The objective of this review is to provide an overview of how basic science discoveries are elucidating essential innate host defenses in the kidney and urinary tract. In doing so, we highlight how these findings may ultimately translate into the clinic as new biomarkers or therapies for urinary tract infection.

Keywords

Urinary tract infection Innate immunity Pyelonephritis Pattern recognition receptors Cytokines Antimicrobial peptides 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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© IPNA 2019

Authors and Affiliations

  1. 1.Nephrology and Urology Research Affinity GroupNationwide Children’s HospitalColumbusUSA
  2. 2.Center of Clinical and Translational ResearchThe Research Institute at Nationwide Children’s HospitalColumbusUSA
  3. 3.Division of UrologyNationwide Children’s HospitalColumbusUSA
  4. 4.Division of Pediatric NephrologyNationwide Children’s HospitalColumbusUSA

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