Voiding cystography: an unusual route of induced hypothyroidism by iodine overdose in two newborns with chronic kidney disease

  • Laure CohenEmail author
  • Marie Pouletty
  • Alice Frerot
  • Anca Tanase
  • Liza Ali
  • Véronique Baudouin
Brief Report



Iatrogenic induced hypothyroidism had been described in newborns and more particularly in preterm infants after cutaneous or intravenous exposure to iodine.


We reported a new risk of iodine intoxication with the cases of two newborns who developed hypothyroidism after intra vesical iodine injection during a cystography, which was performed to confirm antenatal diagnosis of posterior urethral valves (PUV). The newborns both developed transient hypothyroidism due to an iodine overdose.


These two observations suggest that voiding cystourethrography (VCUG) should be carefully considered in newborns with severe uropathy, particularly in the case of renal insufficiency. If indicated, thyroid function should be monitored in the following weeks, and in case of hypothyroidism treatment should be started.


Posterior urethral valves End-stage renal disease Cystourethrography Hypothyroidism Iodine overdose Children 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© IPNA 2019

Authors and Affiliations

  1. 1.Pediatric Nephrology UnitRobert Debré University Hospital – APHPParisFrance
  2. 2.General Pediatrics UnitRobert Debré University Hospital – APHPParisFrance
  3. 3.Neonatology UnitRobert Debré University Hospital – APHPParisFrance
  4. 4.Pediatric Radiology UnitRobert Debré University Hospital – APHPParisFrance
  5. 5.Pediatric Surgery UnitRobert Debré University Hospital – APHPParisFrance

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