CoenzymeQ10 therapy in two sisters with CoQ6 mutations with long-term follow-up
We read with great interest the paper by Stanczyk et al. titled “CoQ10-related sustained remission of proteinuria in a child with COQ6 glomerulopathy—a case report” in the December 2018 issue of Pediatric Nephrology . One of the cases which is mentioned in this paper (4th patient in the table) was followed by us. It was found that she had asymptomatic proteinuria (2+) at the age of 2.5 years at another center when investigated as her older sister had nephrotic syndrome (NS). Kidney biopsy was compatible with focal segmental glomerulosclerosis (FSGS). Oral methylprednisolone therapy was initiated, but she did not tolerate it. She presented to our department at 3 years of age. She was asymptomatic and physical exam was unremarkable, apart from sensorineural deafness. There was consanguineous marriage between the parents. She had 3 g/day of (330 mg/m2/h) proteinuria. Serum creatinine was 0.5 mg/dL and albumin 3.7 g/dL. As no response was seen to 6 weeks of therapy with...
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The authors declare that they have no conflict of interest.
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