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Pediatric Nephrology

, Volume 34, Issue 3, pp 529–532 | Cite as

Idiopathic nephrotic syndrome and rituximab: may we predict circulating B lymphocytes recovery?

  • Jean Daniel Delbet
  • Gael Leclerc
  • Tim UlinskiEmail author
Brief Report

Abstract

Background

Rituximab (RTX) has been shown to be an efficient treatment for steroid-dependent nephrotic syndrome (SDNS). A long B cell depletion period seems to improve the duration of remission. This study reports the duration of B cell depletion after each RTX infusion in patients with nephrotic syndrome.

Methods

We retrospectively report the data of 22 patients with a diagnosis of a SDNS or steroid-resistant nephrotic syndrome (SRNS) and a treatment with RTX in a single center. B cell depletion duration was compared to the first B cell depletion duration and to the previous B cell depletion duration in each patient.

Results

Twenty-two patients (5 girls) were included. Seventy-six periods of B cell depletions were compared to the first B cell depletion duration and to the preceding B cell depletion duration in the same patient. Total duration of B cell depletion was 26 (6–66) months. Individual post-RTX infusion B cell depletion duration was 5.1 (1.6–14) months. Median B cell depletion duration following the first RTX cure for children who had received 1 to 2 infusions at first cure was not statistically different of those who had received 3 to 4 infusions (p = 0.18). Comparing the B cell depletion induced by previous RTX courses and the following B cell depletion, 89.5% of patients had a similar duration within an open interval from 2 months.

Conclusion

Once the individual time interval until B cell recovery is determined, monitoring could be individualized by targeting the expected date of B cell recovery or by performing pre-emptive RTX injections.

Keywords

Nephrotic syndrome Rituximab Children B cell depletion 

Notes

Compliance with ethical standards

The study complies with the Helsinki Declaration and was approved by the local institutional ethics committee.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© IPNA 2018

Authors and Affiliations

  1. 1.Pediatric Nephrology, Department of Pediatric NephrologyArmand Trousseau Hospital, APHPParisFrance
  2. 2.University Pierre and Marie CurieParisFrance
  3. 3.DHU 2iB, Inflammation-ImmunotherapyParisFrance

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