Abstract
Non-adherence remains a significant problem among pediatric (and adult) renal transplant recipients. Non-adherence among solid organ transplant recipients results in US$15–100 million annual costs. Estimates of non-adherence range from 30 to 70% among pediatric patients. Research demonstrates that a 10% decrement in adherence is associated with 8% higher hazard of graft failure and mortality. Focus has begun to shift from patient factors that impact adherence to the contributing healthcare and systems factors. The purpose of this review is to describe problems within the systems implicated in non-adherence and potential solutions that may be related to positive adherence outcomes. Systems issues include insurance and legal regulations, provider and care team barriers to optimal care, and difficulties with transitioning to adult care. Potential solutions include recognition of how systems can work together to improve patient outcomes through improvements in insurance programs, a multi-disciplinary care team approach, evidence-based medical management, pharmacy-based applications and interventions to simplify medication regimens, improved transition protocols, and telehealth/technology-based multi-component interventions. However, there remains a significant lack of reliability in the application of these potential solutions to systems issues that impact patient adherence. Future efforts should accordingly focus on these efforts, likely by leveraging quality improvement and related principles, and on the investigation of the efficacy of these interventions to improve adherence and graft outcomes.
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References
Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC (2004) Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation 77:769–776
Foster BJ, Dahhou M, Zhang X, Platt RW, Samuel SM, Hanley JA (2011) Association between age and graft failure rates in young kidney transplant recipients. Transplantation 92:1237–1243
De Geest S, Denhaerynck K, Dobbels F (2011) Clinical and economic consequences of nonadherence to immunosuppressive drugs in adult solid organ transplantation. Compliance in solid organ transplantation In: Grinyó J (ed) International Transplantation Updates. Permanyer Publications, Barcelona, pp 63–81
Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S (2005) Growing pains: non-adherence with the immunosuppressive regimen in adolescent transplant recipients. Pediatr Transplant 9:381–390
Ettenger RB, Rosenthal JT, Marik JL, Malekzadeh M, Forsythe SB, Kamil ES, Isidro B, Fine R (1991) Improved cadaveric renal transplant outcome in children. Pediatr Nephrol 5:137–142
Shaw RJ, Palmer L, Blasey C, Sarwal M (2003) A typology of non-adherence in pediatric renal transplant recipients. Pediatr Transplant 7:489–493
Osterberg L, Blaschke T (2005) Adherence to medication. N Engl J Med 353:487–497
Chisholm-Burns MA, Spivey CA, Rehfeld R, Zawaideh M, Roe DJ, Gruessner R (2009) Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients. Am J Transplant 9:2497–504
Simons LE, Gilleland J, Blount RL, Amaral S, Berg A, Mee LL (2009) Multidimensional adherence classification system: initial development with adolescent transplant recipients. Pediatr Transplant 13:590–598
Sellares J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF (2012) Understanding the causes of kidney transplant failure: the dominant role of antibodymediated rejection and nonadherence. Am J Transplant 12:388–399
Prendergast MB, Gaston RS (2010) Optimizing medication adherence: an ongoing opportunity to improve outcomes after kidney transplantation. Clin J Am Soc Nephrol 5:1305–1311
Kimmel SE, Troxel AB (2012) Novel incentive based approaches to adherence. Clin Trials 9:689–669
van Gelder T, Silva HT, de Fijter JW, Budde K, Kuypers D, Tyden G, Lohmus A, Sommerer C, Hartmann A, Le Meur Y, Oellerich M, Holt DW, Tönshoff B, Keown P, Campbell S, Mamelok RD (2008) Comparing mycophenolate mofetil regimens for de novo renal transplant recipients: the fixed-dose concentration-controlled trial. Transplantation 86:1043–1051
System USRD (2009) USRDS 2009 annual data report: atlas of chronic kidney disease and end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda
IMS Institute for Healthcare Informatics (2013) Avoidable costs in US health care. http://www.imshealth.com/deployedfiles/imshealth/Global/Content/Corporate/IMS%20Institute/RUOM-2013/IHII_Responsible_Use_Medicines_2013.pdf. Accessed 16 June 2016
Benjamin RM (2012) Medication adherence: helping patients take their medicines as directed. Public Health Rep 127:2–3
Hansen R, Seifeldin R, Noe L (2007) Medication adherence in chronic disease: issues in posttransplant immunosuppression. Transplant Proc 39:1287–1300
Sabaté E (2003) Adherence to long-term therapies: evidence for action. World Health Organization, Geneva
Foster B, Pai LH (2014) Adherence in adolescent and young adult kidney transplant recipients. Open Urol Nephrol J 7:133–143
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X (2008) Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2:CD000011
Dew MA, Dabbs AD, Myaskovsky L, Shyu S, Shellmer DA, DiMartini AF, Steel J, Unruh M, Switzer GE, Shapiro R, Greenhouse JB (2009) Meta-analysis of medical regimen adherence outcomes in pediatric solid organ transplantation. Transplantation 88:736–746
Ortega F, Díaz-Corte C, Valdés C (2015) Adherence to immunosuppressor medication in renal transplanted patients. World J Clin Urol 4:27–37
Dobbels F, Ruppar T, De Geest S, Decorte A, Van Damme-Lombaerts R, Fine RN (2010) Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: a systematic review. Pediatr Transplantation 14:603–613
Ishitani M, Isaacs R, Norwood V, Nock S, Lobo P (2000) Predictors of graft survival in pediatric living-related kidney transplant recipients. Transplantation 70:235–246
Magee JC, Bucuvalas JC, Farmer DG, Harmon WE, Hulbert-Shearon TE, Mendeloff EN (2004) Pediatric transplantation. Am J Transplant 4[Suppl 9]:54–71
Smith JM, Ho PL, McDonald RA (2002) Renal transplant outcomes in adolescents: a report of the North American Pediatric Renal Transplant Cooperative Study. Pediatr Transplant 6:493–499
Bunchman TE (2000) Compliance in pediatric transplant. Pediatr Transplant 4:165–169
Fennell RS, Tucker C, Pedersen T (2001) Demographic and medical predictors of medication compliance among ethnically different pediatric renal transplant patients. Pediatr Transplant 5:343–348
Wolff G, Strecker K, Vester U, Latta K, Ehrich JH (1998) Non-compliance following renal transplantation in children and adolescents. Pediatr Nephrol 12:703–708
Delucchi A, Gutierrez H, Arrellano P, Slater C, Meneses M, López I (2008) Factors that influence nonadherence in immunosuppressant treatment in pediatric transplant recipients: a proposal for an educational strategy. Transplant Proc 40:3241–3243
Gordon EJ, Prohaska TR, Gallant MP, Siminoff L (2007) Adherence to immunosuppression: a prospective diary study. Transplant Proc 39:3081–3085
Weng FL, Israni AK, Joffe MM, Hoy T, Gaughan CA (2005) Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol 16:1839–1848
Denhaerynck K, Desmyttere A, Dobbels F, Moons P, Young J, Siegal B, Greenstein S, Steiger J, Vanrenterghem Y, Squifflet JP, van Hooff JP, De Geest S (2006) Prevalence of noncompliance with the immunosuppressive regimen in North American and European renal transplant recipients. Prog Transplant 16:206–214
Johnson SB (1992) Measuring adherence. Diabetes Care 15:1658–1667
Butler JA, Peveler RC, Roderick P, Horne R, Mason JC (2004) Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation 77:786–789
Shemesh E, Shneider BL, Savitzky JK, Arnott L, Gondolesi GE, Krieger NR, Kerkar N, Magid MS, Stuber ML, Schmeidler J, Yehuda R, Emre S (2004) Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 113:825–832
Burney KD, Krishnan K, Ruffin MT, Zhang D, Brenner DE (1996) Adherence to single daily dose of aspirin in a chemoprevention trial. An evaluation of self-report and microelectronic monitoring. Arch Fam Med 5:297–300
Bender B, Wamboldt FS, O’Connor SL (2000) Measurement of children’s asthma medication adherence by self report, mother report, canister weight, and Doser CT. Ann Allergy Asthma Immunol 85:416–421
Lieber SR, Helcer J, Shemesh E (2015) Monitoring drug adherence. Transplant Rev (Orlando) 29:73–77
McGrady ME, Hommel K (2013) Medication adherence and health care utilization in pediatric chronic illness: a systematic review. Pediatrics 132:730–740
Federal Interagency Forum on Child and Family Statistics (2012) America’s children in brief: key national indicators of well-being. U.S. Government Printing Office, Washington, DC
Butkus DE, Meydrech EF, Raju SS (1992) Racial differences in the survival of cadaveric renal allografts: overriding effects of HLA matching and socioeconomic factors. N Engl J Med 327:840–845
Woodward RS, Schnitzler MA, Lowell JA, Spitznagel EL, Brennan DC (2001) Effect of extended coverage of immunosuppressive medications by medicare on the survival of cadaveric renal transplants. Am J Transplant 1:69–73
Gill JS, Tonelli M (2012) Penny wise, pound foolish? Coverage limits on immunosuppression after kidney transplantation. N Engl J Med 366:586–589
Mattke S, Mengistu T, Klautzer L, Sloss EM, Brook RH (2015) Improving care for chronic conditions: current practices and future trends in health plan programs. RAND Corporation, Santa Monica
Evans RW, Applegate WH, Briscoe DM, Cohen DJ, Rorick CC, Murphy BT, Madsen JC (2010) Cost-related immunosuppressive medication nonadherence among kidney transplant recipients. Clin J Am Soc Nephrol 5:2323–2328
Callahan ST, Cooper WO (2007) Continuity of health insurance coverage among young adults with disabilities. Pediatrics 119:1175–1180
Gordon EJ, Gallant M, Sehgal AR, Conti D, Siminoff LA (2009) Medication-taking among adult renal transplant recipients: barriers and strategies. Transpl Int 22:534–545
Goins RT, Williams KA, Carter MW, Spencer SM, Solovieva T (2005) Perceived barriers to health care access among rural older adults: a qualitative study. J Rural Health 21:206–213
Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group (2009) KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 9[Suppl 3]:S1–S157
Heemann U, Abramowicz D, Spasovski G, Vanholder R; European Renal Best Practice Work Group on Kidney Transplantation (2011) Endorsement of the Kidney Disease Improving Global Outcomes (KDIGO) guidelines on kidney transplantation: a European Renal Best Practice (ERBP) position statement. Nephrol Dial Transplant 26:2099–2106
Bia M, Adey DB, Bloom RD, Chan L, Kulkarni S, Tomlanovich S (2010) KDOQI US commentary on the 2009 KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Kidney Dis 56:189–218
Knoll GA, Blydt-Hansen TD, Campbell P, Cantarovich M, Cole E, Fairhead T, Gill JS, Gourishankar S, Hebert D, Hodsman A, House AA, Humar A, Karpinski M, Kim SJ, Mainra R, Prasad GV (2010) Canadian Society of Transplantation and Canadian Society of Nephrology commentary on the 2009 KDIGO clinical practice guidelines for the care of kidney transplant recipients. Am J Kidney Dis 56:219–246
Hooper DK, Williams JC, Carle AC, Amaral S, Chand DH, Ferris ME, Patel HP, Licht C, Barletta GM, Zitterman V, Mitsnefes M, Patel UD (2013) The quality of cardiovascular disease care for adolescents with kidney disease: a Midwest Pediatric Nephrology Consortium study. Pediatr Nephrol 28:939–949
Wilson AC, Greenbaum LA, Barletta GM, Chand D, Lin JJ, Patel HP, Mitsnefes M (2010) High prevalence of the metabolic syndrome and associated left ventricular hypertrophy in pediatric renal transplant recipients. Pediatr Transplant 14:52–60
Morales JM, Varo E, Lazaro P (2012) Immunosuppressant treatment adherence, barriers to adherence and quality of life in renal and liver transplant recipients in Spain. Clin Transplant 26:369–376
Saini SD, Schoenfeld P, Kaulback K, Dubinsky MC (2009) Effect of medication dosing frequency on adherence in chronic diseases. Am J Manag Care 15:e22–33
Zelikovsky N, Schast AP, Palmer J, Meyers KE (2008) Perceived barriers to adherence among adolescent renal transplant candidates. Pediatr Transplant 12:300–308
Bullington P, Pawola L, Walker R, Valenta A, Briars L, John E (2007) Identification of medication non-adherence factors in adolescent transplant patients: The patient’s viewpoint. Pediatr Transplant 11:914–921
Simons LE, McCormick ML, Mee LL, Blount RL (2009) Parent and patient perspectives on barriers to medication adherence in adolescent transplant recipients. Pediatr Transplant 13:338–347
Warady BA, Mudge C, Wiser B, Wiser M, Rader B (1996) Transplant allograft loss in the adolescent patient. Adv Ren Replace Ther 3:154–165
Meyers KE, Thomson PD, Weiland H (1996) Noncompliance in children and adolescents after renal transplantation. Transplantation 62:186–189
Watson AR (2000) Non-compliance and transfer from paediatric to adult transplant unit. Pediatr Nephrol 14:469–472
Foster BJ, Platt RW, Dahhou M, Zhang X, Bell LE, Hanley JA (2011) The impact of age at transfer from pediatric to adult-oriented care on renal allograft survival. Pediatr Transplant 15:750–759
Annunziato RA, Emre S, Shneider BL, Barton C, Dugan CA, Shemesh E (2007) Adherence and medical outcomes in pediatric liver transplant recipients who transition to adult services. Pediatr Transplant 11:608–614
Akchurin OM, Melamed ML, Hashim BL, Kaskel FJ, Del Rio M (2014) Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. Pediatr Transplant 18:538–548
Koshy SM, Hebert D, Lam K, Stukel TA, Guttmann A (2009) Renal allograft loss during transition to adult healthcare services among pediatric renal transplant patients. Transplantation 87:1733–1736
Hauser ES, Dorn L (1999) Transitioning adolescents with sickle cell disease to adult-centered care. Pediatr Nurs 25:479–488
Patterson DL, Lanier C (1999) Adolescent health transition: focus group study of teens and young adults with special health care needs. Fam Community Health 22:43–58
Westwood A, Henley LD, Wilcox P (1999) Transition from paediatric to adult care for persons with cystic fibrosis: patient and parent perspectives. J Paediatr Child Health 25:442–445
Annunziato RA, Hogan B, Barton C, Miloh T, Arnon R, Iyer K, Kerkar N (2010) A translational and systemic approach to transferring liver transplant recipients from pediatric to adult‐oriented care settings. Pediatr Transplant 14:823–829
Kipps S, Bahu T, Ong K, Ackland FM, Brown RS, Fox CT, Griffin NK, Knight AH, Mann NP, Neil HAW, Simpson H, Edge JA, Dunger DB (2002) Current methods of transfer of young people with type 1 diabetes to adult services. Diabet Med 19:649–654
Rosen DS (2003) Transition to adult health care for adolescents and young adults with chronic conditions. J Adolesc Health 33:309–311
El-Matary W (2009) Transition of children with inflammatory bowel disease: big task, little evidence. World J Gastroenterol 15:3744–3747
Alpay H (2008) Transition of the adolescent patient to the adult clinic. Perit Dial Int 29[Suppl 2]:S180–S182
Berben L, Denhaerynch K, Dobbels F, Engberg S, Vanhaeck J, Crespo-Leiro MG, Russell CL, De Geest S, for the BRIGHT Study Consortium (2015) Building research initiative group: chronic illness management and adherence in transplantation (BRIGHT) study: study protocol. J Adv Nurs 71:642–654
Epping-Jordan JE, Pruitt SD, Bengoa R, Wagner EH (2004) Improving the quality of health care for chronic conditions. Qual Safe Health Care 13:299–305
Yach D (2002) Innovative care for chronic conditions—building blocks for action. World Health Organization, Geneva
Bronfenbrenner U (1977) Toward an experimental ecology of human development. Am Psychol 32:513–531
Bronfenbrenner U (1980) The ecology of human development. Experiments by nature and design. Harvard University Press, Cambridge
Stoll BJ, Stevenson DK, Wise PH (2013) The transformation of child health research: innovation, market failure, and the public good. JAMA 309:1779–1780
Bissonnette J, Woodend K, Davies B, Stacey D, Knoll GA (2013) Evaluation of a collaborative chronic care approach to improve outcomes in kidney transplant recipients. Clin Transplant 27:232–238
Wolf FM, Guevara JP, Grum CM, Clark NM, Cates CJ (2003) Educational interventions for asthma in children. Cochrane Database Syst Rev 1:CD000326
Cafazzo JA, Casselman M, Hamming N, Katzman DK, Palmert MR (2012) Design of an mHealth app for the self-management of adolescent type I diabetes: a pilot study. J Med Internet Res 14:e70
Oberlin SR, Parente ST, Pruett TL (2016) Improving medication adherence among kidney transplant recipients: Findings from other industries, patient engagement, and behavioral economics—a scoping review. SAGE Open Med 4:2050312115625026
Busse R, Blumel M, Scheller-Kreinsen D, Zentner A (2010) Tackling chronic diseases in Europe. Strategies, interventions and challenges. The European Observatory on Health Systems and Policies, Brussels
Dobbels F, De Bleser L, Berben L, Kristanto P, Dupont L, Nevens F, Vanhaecke J, Verleden G, De Geest S (2017) Efficacy of a medication adherence enhancing intervention in transplantation: the MAESTRO-Tx trial. J Heart Lung Transplant. doi:10.1016/j.healun.2017.01.007
Pahl E, Grady K (2015) Pediatric heart transplantation: transitioning to adult care (TRANSIT). Unpublished clinical trial, Clinical Trials Identifier: NCT02090257. https://clinicaltrials.gov/show/NCT02090257
Dharnidharka VR, Fiorina P, Harmon WE (2014) Kidney transplantation in children. N Engl J Med 371:549–558
Hooper DK, Kirby CL, Margolis PA, Goebel J (2013) Reliable individualized monitoring improves cholesterol control in kidney transplant recipients. Pediatrics 131:e1271–e1279
Varnell CD, Loiselle K, Pai AL, Modi A, Hooper DK (2015) Assessing adherence barriers in pediatric kidney transplant recipients (abstract SA-PO1023). J Am Soc Nephrol 26:869A
Shemesh E (2016) Barriers to adherence-to screen or not to screen, that is the question. Pediatr Transplant 20:188–190
Danziger-Isakov L, Frazier T, Worley S, Williams N, Shellmer D, Dharnidharka VR, Gupta NA, Ikle D, Sweet SC, CTOTC-05 Consortium (2016) Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation. Pediatr Transplant 20:307–315
Loiselle KA, Gutierrez-Colina AM, Eaton CK, Simons LE, Devine KA, Mee LL, Blount RL (2015) Longitudinal stability of medication adherence among adolescent solid organ transplant recipients. Pediatr Transplant 19:428–435
Lieber SR, Shemesh E (2015) Longitudinal stability of medication adherence: trying to decipher an important construct. Pediatr Transplant 19:348–350
Singh N, Von Visger J, Zachariah M (2015) Extended release once a day tacrolimus. Curr Opin Organ Transplant 20:657–662
Vincenti F, Rostaing L, Grinyo J, Rice K, Steinberg S, Gaite L, Moal MC, Mondragon-Ramirez GA, Kothari J, Polinsky MS, Meier-Kriesche HU, Munier S, Larsen C (2016) Belatacept and long-term outcomes in kidney transplantation. N Engl J Med 374:333–343
Heffron TG, Pescovitz MD, Florman S, Kalayoglu M, Emre S, Smallwood G, Wisemandle K, Anania C, Dhadda S, Sawamoto T, Keirns J, Fitzsimmons W, First MR (2007) Once-daily tacrolimus extended-release formulation: 1-year post-conversion in stable pediatric liver transplant recipients. Am J Transplant 7:1609–1615
Min SI, Ha J, Kang GH, Ahn S, Park T, Park DD, Kim SM, Hong HJ, Min SK, Ha IS, Kim SJ (2013) Conversion of twice-daily tacrolimus to once-daily tacrolimus formulation in stable pediatric kidney transplant recipients: pharmacokinetics and efficacy. Am J Transplant 13:2191–2197
Clayton P, McDonald S, Chapman J, Chadban S (2012) Mycophenolate versus azathioprine for kidney transplantation: a 15-year follow-up of a randomized trial. Transplantation 94:152–158
Wagner M, Earley AK, Webster AC, Schmid CH, Balk EM, Uhlig K (2015) Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients. Cochrane Database Syst Rev 12:CD007746
Kahana S, Drotar D, Frazier TJ (2008) Meta-analysis of psychological interventions to promote adherence to treatment in pediatric chronic health conditions. Pediatr Psychol 33:590–611
Nansel TR, Iannotti RJ, Simons-Morton BG, Plotnick LP, Clark LM, Zeitzoff L (2009) Long-term maintenance of treatment outcomes: diabetes personal trainer intervention for youth with type 1 diabetes. Diabetes Care 32:807–809
Miloh T, Annunziato R, Arnon R, Warshaw J, Parkar S, Suchy F, Iyer K, Kerkar N (2009) Improved adherence and outcomes for pediatric liver transplant recipients by using text messaging. Pediatrics 124:e844–e850
Foster BJ, Pai A, Zhao H, Furth S (2014) The TAKE-IT study: aims, design, and methods. BMC Nephrol 15:139
Tschida S, Aslam S, Lal LS, Khan TT, Shrank WH, Bhattarai GR, Montague-Clouse JC, Sahli BD, Newcomer LN (2012) Outcomes of a specialty pharmacy program for oral oncology medications. Am J Pharm Benefits 4:165–174
Schwartz R, Eng K, Frieze D, Gosselin T, Griffith N, Seung A, Hinkel J, Johnson S, Li E, Szabatura A, Wong M (2010) NCCN task force report: specialty pharmacy. J Natl Compr Canc Netw 8:1–12
Hlubocky J, Stuckey L, Schuman A, Stevenson J (2012) Evaluation of a transplantation specialty pharmacy program. Am J Health Syst Pharm 69:340–347
Capsule Pharmacy. Our Pharmacy. Capsule Corporation, New York, NY. https://www.capsulecares.com/. Accessed 25 June 2016
Circadian Design, Inc. Round Refill©. Modernize the medicine cabinet. Circadian Design, Inc., San Francisco, CA. https://roundhealth.co/refill/. Accessed 25 June 2016
Pill Pack. Our service. Pill Pack, Manchester, NH. https://www.pillpack.com/service. Accessed 25 June 2016
Kannisto KA, Koivunen MH, Valimaki MA (2014) Use of mobile phone text message reminders in health care services: a narrative literature review. J Med Internet Res 16:e222
Shellmer D, Dew M, Mazariegos G, Dabbs A (2016) Development and field testing of Teen Pocket PATH, a mobile health application to improve medication adherence in adolescent solid organ transplant recipients. Pediatr Transplant 20:130–140
Transplant Hero. About. Transplant Hero LLC. http://www.transplanthero.com/about/. Accessed 10 Feb 2017
Heldenbrand S, Martin BC, Gubbins PO, Hadden K, Renna C, Shilling R, Dayer L (2016) Assessment of medication adherence app features, functionality, and health literacy level and the creation of a searchable Web-based adherence app resource for health care professionals and patients. J Am Pharm Assoc 56:293–302
Eisenberger U, Wüthrich RP, Bock A, Ambühl P, Steiger J, Intondi A, Kuranoff S, Maier T, Green D, DiCarlo L, Feutren G, DeGeest S (2013) Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants. Transplantation 96:245–250
Proteus Digital Health. Discover. Proteus Digital Health, Inc., Redwood City, CA. http://www.proteus.com/discover/ Accessed 10 Feb 2017
Paraskeva M, Martin R, Attard K, Levvey B, Marshal J, Tarrant B, Ivulich S, Westall GP (2016) Improving health management: the development of an adolescent specific education program. J Heart Lung Transplant 35:S349–S350
Fredericks EM, Zelikovsky N, Aujoulat I, Hames A, Wray J (2014) Post‐transplant adjustment–the later years. Pediatr Transplant 18:675–688
Harden PN, Walsh G, Bandler N, Bradley S, Lonsdale D, Taylor J, Marks SD (2012) Bridging the gap: an integrated paediatric to adult clinical service for young adults with kidney failure. BMJ 344, e3718
Jerson B, D’urso C, Arnon R, Miloh T, Iyer NK, Annunziato RA (2013) Adolescent transplant recipients as peer mentors: a program to improve self-management and health-related quality of life. Pediatr Transplant 17:612–620
Norman S (2006) The use of telemedicine in psychiatry. J Psychiatr Ment Health Nurs 13:771–777
Saab PG, McCalla JR, Coons HL, Christensen AJ, Kaplan R, Johnson SB, Ackerman MD, Stepanski E, Krantz DS, Melamed B (2004) Technological and medical advances: implications for health psychology. Health Psychol 23:142
Hilt RJ, Barclay RP, Bush J, Stout B, Anderson N, Wignall JR (2015) A statewide child telepsychiatry consult system yields desired health system changes and savings. Telemed J E Health 21:533–537
O’Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J (2007) Is telepsychiatry equivalent to face-to-face psychiatry? Results from a randomized controlled equivalence trial. Psychiatr Serv 58:836–843
Malhotra S, Chakrabarti S, Shah R (2013) Telepsychiatry: promise, potential, and challenges. Indian J Psychiatry 55:3
Gardner MR, Jenkins SM, O’Neil DA, Wood DL, Spurrier BR, Pruthi S (2015) Perceptions of video-based appointments from the patient’s home: a patient survey. Telemed J E Health 21:281–285
Steel K, Cox D, Garry H (2011) Therapeutic videoconferencing interventions for the treatment of long-term conditions. J Telemed Telecare 17:109–117
Blumenthal JA, Babyak MA, Carney RM, Keefe FJ, Davis RD, Lacaille RA, Carney RM, Freedland KE, Trulock E, Palmer SM (2006) Telephone-based coping skills training for patients awaiting lung transplantation. J Consult Clin Psychol 74:535–544
Leimig R, Gower G, Thompson D, Winsett R (2008) Infection, rejection, and hospitalizations in transplant recipients using telehealth. Prog Transplant 18:97–102
Thompson DA, Leimig R, Gower G, Winsett RP (2009) Assessment of depressive symptoms during post-transplant follow-up care performed via telehealth. Telemed J E Health 15:700–706
Lounsberry JJ, MacRae H, Angen M, Hoeber M, Carlson LE (2010) Feasibility study of a telehealth delivered, psychoeducational support group for allogeneic hematopoietic stem cell transplant patients. Psychooncology 19:777–781
Hommel KA, Herzer M, Ingerski LM, Hente E, Denson LA (2011) Individually tailored treatment of medication nonadherence. J Pediatr Gastroenterol Nutr 53:435–439
Hommel KA, Hente EA, Odell S, Herzer M, Ingerski LM, Guilfoyle SM, Denson LA (2012) Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol 24:64–69
Hommel KA, Hente E, Herzer M, Ingerski LM, Denson LA (2013) Telehealth behavioral treatment for medication nonadherence: a pilot and feasibility study. Eur J Gastroenterol Hepatol 25:469–473
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The authors wish to dedicate this article to the memory of Dennis Drotar, PhD, who recently passed away and without whose mentorship and leadership in the field the work summarized and referenced here would not have been possible.
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Steinberg, E.A., Moss, M., Buchanan, C.L. et al. Adherence in pediatric kidney transplant recipients: solutions for the system. Pediatr Nephrol 33, 361–372 (2018). https://doi.org/10.1007/s00467-017-3637-0
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DOI: https://doi.org/10.1007/s00467-017-3637-0