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Pediatric Nephrology

, Volume 21, Issue 11, pp 1730–1738 | Cite as

Body composition and nutritional intake in children with chronic kidney disease

  • Rajeeb Rashid
  • Esther Neill
  • Wilma Smith
  • Diane King
  • T. James Beattie
  • Anna Murphy
  • Ian J. Ramage
  • Heather Maxwell
  • S. Faisal AhmedEmail author
Original Article

Abstract

The aim of this study was to assess body composition in children with chronic renal failure (CRF) and post renal transplantation (Tx), and to compare it to body mass index (BMI) and nutritional intake. Dietary assessment using 3-day diaries, total and regional body composition assessment by dual x-ray energy absorptiometry of 50 CRF children (29M, 21F), median age 8.9 yrs and 50 Tx children (32M, 18F), median age 12.9 yrs. BMI, percentage fat mass (%FM) and lean mass (LM) were corrected for height and expressed as SDS (HSDS). In both groups, BMIHSDS was lower than %FMHSDS and higher than LMHSDS (p<0.05). In the Tx group, there were associations on bivariate analysis between energy & protein intake and BMIHSDS & %FMHSDS (r,0.5, p<0.05), and between LMHSDS and protein intake (r,0.5, p<0.05). On multivariate analysis, there was an association between LMHSDS and time since transplantation (r,−0.4, p<0.05). Children in the CRF and Tx groups had a high percentage predicted trunk:leg FM ratio of 148% and 157%, respectively. Children with CRF and Tx have discordant body composition with a relatively high FM and low LM, which is not reflected by BMI. In addition, they appear to have an increased level of central adiposity that may predispose them to increased morbidity in later life.

Keywords

Chronic renal failure Post-Renal Transplantation Lean Mass Fat Mass DXA 

Abbreviations

CRF

chronic renal failure

Tx

post-renal transplantation

BMI

body mass index

DXA

dual X-ray energy absorptiometry

rhGH

Recombinant Growth Hormone

FM

fat mass

LM

lean mass

HSDS

height standard deviation scores

DRV

dietary reference values

RNI

reference nutrient intake

ESRD

end stage renal disease

GFR

glomerular filtration rate

ppFR

percentage predicted fat trunk:leg ratio

BMC

bone mineral content

TBW

total body water

Notes

Acknowledgements

The investigators are indebted to Jane Logan for her technical assistance and the Yorkhill Children’s Foundation and the Kidney Kids Scotland for their generous support.

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Rajeeb Rashid
    • 1
  • Esther Neill
    • 2
  • Wilma Smith
    • 1
  • Diane King
    • 2
  • T. James Beattie
    • 2
  • Anna Murphy
    • 2
  • Ian J. Ramage
    • 2
  • Heather Maxwell
    • 2
  • S. Faisal Ahmed
    • 1
    Email author
  1. 1.Bone & Endocrine Research Group, Dept of Child HealthRoyal Hospital for Sick Children YorkhillGlasgowUK
  2. 2.Renal Unit, Royal Hospital for Sick ChildrenGlasgowUK

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