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Pediatric Nephrology

, Volume 21, Issue 8, pp 1194–1196 | Cite as

Biopsy-proven acute tubular necrosis in a child attributed to vancomycin intoxication

  • Brandy Alexandra Wicklow
  • Malcolm Robert Ogborn
  • Ian William Gibson
  • Tom David Blydt-HansenEmail author
Brief Report

Abstract

Acute renal failure in children treated with vancomycin typically presents with interstitial nephritis. There is debate as to the extent of direct tubular toxicity attributable to vancomycin, especially in the absence of aminoglycoside treatment. We report a case of acute tubular necrosis (ATN) associated with vancomycin toxicity in an 8-year-old boy where there is no likely alternate explanation for toxic or ischemic injury. Treatment with hemodialysis resulted in the elimination of vancomycin from the circulation and subsequent improvement in renal function.

Keywords

Acute tubular injury Acute renal failure Drug toxicity Therapeutic drug monitoring Hemodialysis Nephrotoxicity Free radical 

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Brandy Alexandra Wicklow
    • 1
  • Malcolm Robert Ogborn
    • 2
  • Ian William Gibson
    • 3
  • Tom David Blydt-Hansen
    • 2
    Email author
  1. 1.Department of Pediatrics and Child Health, Winnipeg Children’s HospitalUniversity of ManitobaWinnipegCanada
  2. 2.Department of Pediatrics and Child Health (Nephrology), Winnipeg Children’s HospitalUniversity of ManitobaWinnipegCanada
  3. 3.Department of Pathology, Health Sciences CenterUniversity of ManitobaWinnipegCanada

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