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Pediatric Nephrology

, Volume 21, Issue 7, pp 1056–1057 | Cite as

Barttin mutations in antenatal Bartter syndrome with sensorineural deafness

  • Ferda OzluEmail author
  • Hacer Yapicioğlu
  • Mehmet Satar
  • Nejat Narli
  • Kenan Ozcan
  • Mithat Buyukcelik
  • Martin Konrad
  • Osman Demirhan
Letter to the Editors

Sirs,

We have observed two patients with antenatal and postnatal findings pathognomonic for antenatal Bartter syndrome (aBS). In addition, both had sensorineural deafness. This entity is known as aBS with sensorineural deafness (BSND).

Case reports

Case 1

The male patient had been born at 30 weeks of gestation (weight 1,360 g) to consanguineous parents. Pregnancy was complicated by severe polyhydramnios. Findings at his physical examination were normal except for a triangular face, large eyes, protruding ears, tachypnea and retractions. He rapidly developed renal salt wasting, hyper-reninemic hyperaldosteronism, hypokalemic metabolic alkalosis, and impaired renal function [creatinine (Crea) 1.5 mg/dl]. The diagnosis of antenatal Bartter syndrome (aBS) was suspected. On day 49 oral administration of indomethacin was started (2–3 mg/kg per day), which could not help to regulate serum potassium levels. Instead, upon indomethacin treatment, renal function further deteriorated (Crea...

Keywords

Indomethacin Blood Urea Nitrogen Fluid Loss Newborn Period Excessive Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Ferda Ozlu
    • 1
    Email author
  • Hacer Yapicioğlu
    • 1
  • Mehmet Satar
    • 1
  • Nejat Narli
    • 1
  • Kenan Ozcan
    • 1
  • Mithat Buyukcelik
    • 2
  • Martin Konrad
    • 4
  • Osman Demirhan
    • 3
  1. 1.Division of Neonatology, Faculty of MedicineÇukurova UniversityAdanaTurkey
  2. 2.Division of Pediatric Nephrology, Faculty of MedicineÇukurova UniversityAdanaTurkey
  3. 3.Division of Medical Biology, Faculty of MedicineÇukurova UniversityAdanaTurkey
  4. 4.University Children’s HospitalBerneSwitzerland

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