Pediatric Nephrology

, Volume 21, Issue 6, pp 782–784 | Cite as

Analysis of a uteroglobin gene polymorphism in childhood Henoch–Schonlein purpura

  • Eli M. EisensteinEmail author
  • Moonsuk Choi
Original Article


Uteroglobin (UG) is a pleiotropic protein with anti-inflammatory properties. Mice rendered genetically incapable of expressing UG develop a form of renal disease that closely resembles human IgA nephropathy (IgAN). Furthermore, a single nucleotide polymorphism in the UG gene (A38G) has been associated with rapid progression of human IgAN. We examined whether the A38G polymorphism is associated with childhood Henoch–Schonlein purpura (HSP), a form of vasculitis associated with IgAN-like renal disease. We examined the prevalence of the A38G polymorphism in 34 children with HSP and in 38 ethnically matched controls. Only one patient had clinically evident renal involvement. As compared with controls, the prevalence of the 38G allele was slightly increased in children with HSP, but this increase was not statistically significant. Our results do not support a role for UG in susceptibility to childhood HSP in the population studied. Larger studies involving more patients with renal disease will be necessary to define whether UG is associated with increased risk for HSP nephritis.


Uteroglobin Henoch–Schonlein purpura IgA nephropathy Polymorphism 



The authors wish to thank Dr. Anil Mukherjee for assistance in coordinating this study and preparing the manuscript.


  1. 1.
    Gairdner D (1948) The Henoch–Schonlein syndrome (anaphylactoid purpura). Q J Med 66:95–122Google Scholar
  2. 2.
    Saulsbury FT (1999) Henoch–Schonlein purpura in children. Report of 100 patients and review of the literature. Medicine (Baltimore) 78:395–409CrossRefGoogle Scholar
  3. 3.
    Szer IS (2001) Henoch–Schonlein purpura. In: Klippel JH, Dieppe PA (eds) Rheumatology, 2nd edn. Philadelphia, Mosby, 7(28):1–4Google Scholar
  4. 4.
    Counahan R, Winterborn MH, White RH, Heaton JM, Meadow SR, Bluett NH, Swetschin H, Cameron JS, Chantler C (1977) Prognosis of Henoch–Schonlein nephritis in children. Br Med J 2:11–14CrossRefGoogle Scholar
  5. 5.
    Nielsen HE (1988) Epidemiology of Schonlein-Henoch purpura. Acta Paediatr Scand 77:125–131CrossRefGoogle Scholar
  6. 6.
    Coppo R, Gianoglio B, Porcellini MG, Maringhini S (1998) Frequency of renal diseases and clinical indications for renal biopsy in children (report of the Italian national registry of renal biopsies in Children). Group of renal immunopathology of the Italian society of pediatric nephrology and group of renal immunopathology of the Italian society of nephrology. Nephrol Dial Transplant 13:293–297CrossRefGoogle Scholar
  7. 7.
    Davin JC, Weening JJ (2001) Henoch–Schonlein purpura nephritis: an update. Eur J Pediatr 160:689–695CrossRefGoogle Scholar
  8. 8.
    Amoli MM, Thomson W, Hajeer AH, Calvino MC, Garcia-Porrua C, Ollier WE, Gonzalez-May MA (2001) HLA-DRB1*01 association with Henoch–Schonlein purpura in patients from northwest Spain. J Rheumatol 28:1266–1270PubMedGoogle Scholar
  9. 9.
    Yang YH, Lai HJ, Kao CK, Lin YT, Chiang BL (2004) The association between transforming growth factor-beta gene promoter C-509T polymorphism and Chinese children with Henoch–Schonlein purpura. Pediatr Nephrol 19:972–975CrossRefGoogle Scholar
  10. 10.
    Yoshioka T, Xu YX, Yoshida H, Shiraga H, Muraki T, Ito K (1998) Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch–Schonlein purpura nephritis. Arch Dis Child 79:394–399CrossRefGoogle Scholar
  11. 11.
    Amoli MM, Thomson W, Hajeer AH, Calvino MC, Garcia-Porrua C, Ollier WE, Gonzalez-May MA (2002) Interleukin 1 receptor antagonist gene polymorphism is associated with severe renal involvement and renal sequelae in Henoch–Schonlein purpura. J Rheumatol 29:1404–1407PubMedGoogle Scholar
  12. 12.
    Amoli MM, Thomson W, Hajeer AH, Calvino MC, Garcia-Porrua C, Ollier WE, Gonzalez-May MA (2002) Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. J Rheumatol 29:2367–2370PubMedGoogle Scholar
  13. 13.
    Amoli MM, Calvino MC, Garcia-Porrua C, Llorca J, Ollier WE, Gonzalez-Gay MA (2004) Interleukin 1beta gene polymorphism association with severe renal manifestations and renal sequelae in Henoch–Schonlein purpura. J Rheumatol 31:295–298PubMedGoogle Scholar
  14. 14.
    Mukherjee AB, Kundu GC, Mantile-Selvaggi G, Yuan CJ, Mantal AK, Chattopadhyay S, Zheng F, Pittabiraman N, Zhang Z (1999) Uteroglobin: a novel cytokine? Cell Mol Life Sci 55:771–787CrossRefGoogle Scholar
  15. 15.
    Mandal AK, Zhang Z, Ray R, Choi MS, Chowdhury B, Pattibiraman N, Mukherjee AB (2004) Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions. J Exp Med 199:1317–1330CrossRefGoogle Scholar
  16. 16.
    Zheng F, Kundu GC, Zhang Z, Ward J, DeMayo F, Mukherjee AB (1999) Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice. Nat Med 5:1018–1025CrossRefGoogle Scholar
  17. 17.
    Choi M, Zhang Z, Ten Kate LP, Collee JM, Gerritsen J, Mukherjee AB (2000) Human uteroglobin gene polymorphisms and genetic susceptibility to asthma. Ann N Y Acad Sci 923:303–306CrossRefGoogle Scholar
  18. 18.
    Szelestei T, Bahring S, Kovacs T, Vas T, Salamon C, Busjahn A, Luft FC, Najy J (2000) Association of a uteroglobin polymorphism with rate of progression in patients with IgA nephropathy. Am J Kidney Dis 36:468–473CrossRefGoogle Scholar
  19. 19.
    Matsunaga A, Numakura C, Kawakami T, Itoh Y, Kawabata I, Masalante I, Suzuki T, Goto T, Itoh K, Hayasaka K (2002) Association of the uteroglobin gene polymorphism with IgA nephropathy. Am J Kidney Dis 39:36–41CrossRefGoogle Scholar
  20. 20.
    Menegatti E, Nardacchione A, Alpa M, Agnes C, Rossi D, Chiara M, Modena V, Sena LM, Roccatello D (2002) Polymorphism of the uteroglobin gene in systemic lupus erythematosus and IgA nephropathy. Lab Invest 82:543–546CrossRefGoogle Scholar
  21. 21.
    Narita I, Saito N, Goto S, Jin S, Omori K, Sakatsume M, Gejyo F (2002) Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. Kidney Int 61:1853–1858CrossRefGoogle Scholar
  22. 22.
    Mills JA, Michel BA, Bloch DA, Calabrese LH, Hunder GG, Arend WP, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW, Masi AT, Mills JA, Stevens MB, Wallace SL, Zvaifler NJ (1990) The American College of Rheumatology 1990 criteria for the classification of Henoch–Schonlein purpura. Arthritis Rheum 33:1114–1121CrossRefGoogle Scholar
  23. 23.
    Kim YS, Kang D, Kwon DY, Park WY, Kim H, Lee DS, Lim CS, Han JS, Kin S, Lee JS (2001) Uteroglobin gene polymorphisms affect the progression of immunoglobulin A nephropathy by modulating the level of uteroglobin expression. Pharmacogenetics 11:299–305CrossRefGoogle Scholar
  24. 24.
    Blazer S, Alon U, Berant M, Korman SH (1981) Henoch–Schonlein syndrome—paucity of renal disease. Review of 71 children. Isr J Med Sci 17:41–44PubMedGoogle Scholar

Copyright information

© IPNA 2006

Authors and Affiliations

  1. 1.Department of PediatricsHadassah Hebrew University Medical CenterJerusalemIsrael
  2. 2.Section of Developmental Genetics, Heritable Disorders BranchNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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