Reply to the letter from K. K. Lau and N. M. Delos Santos
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KeywordsPublic Health Proteinuria Large Study Favorable Outcome Clinical Entity
We are most grateful to Dr. Lau for his comment  on our Letter to the Editors regarding asymptomatic C1q nephropathy . Among their patients, three African–American patients presented with incidental proteinuria. However, in contrast to our patients, all of these three patients ultimately had nephrotic range proteinuria. In addition, they all showed focal segmental glomerulosclerosis in histology, and had less favorable outcomes than our patients. Although the reason for this discrepancy is unclear, their data, as well as our observations, show that a considerable number of patients with asymptomatic proteinuria may have C1q nephropathy. As they mentioned in the Letter, larger studies of well-characterized patients and longer follow-up times for this clinical entity are necessary.