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Pediatric Nephrology

, Volume 21, Issue 5, pp 688–693 | Cite as

Assessment of serum cystatin C in children with congenital solitary kidney

  • Anna WasilewskaEmail author
  • Walentyna Zoch–Zwierz
  • Iwona Jadeszko
  • Tadeusz Porowski
  • Anna Biernacka
  • Alicja Niewiarowska
  • Agata Korzeniecka–Kozerska
Original Article

Abstract

The aim of the study was to assess serum cystatin C level in children with a congenital solitary kidney, depending on their age and compensatory overgrowth of the kidney. The study group (I) consisted of 36 children, 3–21 years of age (median 10.8 years), with a congenital solitary kidney and no other urinary defects. The control group (C) contained 36 healthy children, 5–21 years old (median 10.9 years). Nephelometric methods were used to determine serum cystatin C level, the Jaffe method to assess creatinine concentration and the Schwartz formula to estimate glomerular filtration rate. Kidney length was measured with the patient in a supine position, and overgrowth was estimated (O%) in comparison with the respective kidney in the control group. Serum cystatin C level in group I was higher than that in the control group (P<0.05). Increased values, above 0.95 mg/l, were found in 16/36 (44%) children aged 12–21 years. Glomerular filtration rate (GFR, estimated by the Schwartz formula) and creatinine level in group I were similar to those of the control group (P>0.05). Increased kidney length was found (median 18.2%). Cystatin C concentration was positively correlated with O% (r=0.406, P<0.01) and kidney length to child height ratio (L/H) (r=0.376, P<0.05). We conclude that Increased serum cystatin C concentration in patients with a unilateral congenital solitary kidney occurs after 12 years of age and correlates with compensatory overgrowth of the kidney.

Keywords

Congenital solitary kidney Cystatin C Kidney length 

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Copyright information

© IPNA 2006

Authors and Affiliations

  • Anna Wasilewska
    • 1
    Email author
  • Walentyna Zoch–Zwierz
    • 1
  • Iwona Jadeszko
    • 1
  • Tadeusz Porowski
    • 1
  • Anna Biernacka
    • 1
  • Alicja Niewiarowska
    • 1
  • Agata Korzeniecka–Kozerska
    • 1
  1. 1.1st Department of PaediatricsMedical University of BiałystokBiałystokPoland

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