Pediatric Nephrology

, Volume 21, Issue 5, pp 733–736 | Cite as

Ceftriaxone-related hemolysis and acute renal failure

  • Erkan DemirkayaEmail author
  • Abdullah Avni Atay
  • Ugur Musabak
  • Ali Sengul
  • Faysal Gok
Brief Report


A 5-year-old girl with no underlying immune deficiency or hematologic disease was treated with a combination of ceftriaxone and ampicilline-sulbactam for pneumonia. On the ninth day of the therapy, she developed oliguria, paleness, malaise, immune hemolytic anemia (IHA) and acute renal failure (ARF). Laboratory studies showed the presence of antibodies against ceftriaxone. Acute interstitial nephritis (AIN) was diagnosed by renal biopsy. The patient’s renal insufficiency was successfully treated with peritoneal dialysis without any complications. The patient recovered without any treatment using steroids or other immunosuppressive agents.


Ceftriaxone Immune hemolytic anemia Tubulointerstitial nephritis Acute renal failure Direct antiglobulin test 


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Erkan Demirkaya
    • 1
    Email author
  • Abdullah Avni Atay
    • 2
  • Ugur Musabak
    • 3
  • Ali Sengul
    • 3
  • Faysal Gok
    • 1
  1. 1.Department of Pediatric NephrologyGulhane Military Medical AcademyEtlikTurkey
  2. 2.Department of Pediatric HematologyGulhane Military Medical AcademyEtlikTurkey
  3. 3.Department of ImmunologyGulhane Military Medical AcademyEtlikTurkey

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