Pediatric Nephrology

, Volume 21, Issue 6, pp 793–799 | Cite as

Stature in children with chronic kidney disease: analysis of NAPRTCS database

  • Mouin G. SeikalyEmail author
  • Nina Salhab
  • Debbie Gipson
  • Verna Yiu
  • Donald Stablein
Original Article


Despite recent advances in the management of children with chronic kidney disease (CKD), growth remains suboptimal. The purpose of this study was to evaluate factors associated with short stature in children with CKD. We evaluated the chronic renal failure registry of the North American Pediatric Renal Transplant Cooperative Studies (NAPRTCS) to determine the relations among primary diagnosis, age, race, residual renal function, acidosis, anemia, serum phosphorous, calcium, parathyroid hormone (PTH), albumin, and height at entry into the registry in children with CKD. A total of 5,615 patients were entered into the registry between January 1994 and January 2004. We found that older patients, those with glomerular filtration rate (GFR) >50 ml min−1 1.73 m−2, black patients and patients with focal segmental glomerulosclerosis (FSGS) were at lower risk of being short at entry. Anemia (hematocrit below 33%) was an independent risk factor for short stature. Acidosis, serum phosphorous, calcium, albumin and PTH at registration were poor predictors of short stature. Age, race, primary diagnosis, and residual renal function were associated with short stature in children with CKD.


Chronic Kidney Disease Glomerular Filtration Rate Short Stature Standard Deviation Score Serum Phosphorous 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Glomerular filtration rate


Chronic kidney disease stage 2–4 as defined in [1]


North American Pediatric Renal Transplant Cooperative Studies


Standard deviation score


Recombinant human growth hormone


Estimated creatinine clearance as described in [14] and [15]


Parathyroid hormone


Focal segmental glomerulosclerosis



We are indebted to the secretarial support of Ms. Sharon Blend.


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Copyright information

© IPNA 2006

Authors and Affiliations

  • Mouin G. Seikaly
    • 1
    • 2
    Email author
  • Nina Salhab
    • 2
  • Debbie Gipson
    • 3
  • Verna Yiu
    • 4
  • Donald Stablein
    • 5
  1. 1.Department of PediatricsUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Children’s Medical Center of DallasDallasUSA
  3. 3.Department of PediatricsUniversity of North CarolinaChapel HillUSA
  4. 4.Department of PediatricsUniversity of AlbertaEdmontonCanada
  5. 5.Department of PediatricsThe EMMES CorporationRockvilleUSA

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