Trans-duodenal ampullectomy for ampullary neoplasms: early and long-term outcomes in 36 consecutive patients

  • Gennaro NappoEmail author
  • Damiano Gentile
  • Jacopo Galvanin
  • Giovanni Capretti
  • Cristina Ridolfi
  • Tommasangelo Petitti
  • Paola Spaggiari
  • Silvia Carrara
  • Francesca Gavazzi
  • Alessandro Repici
  • Alessandro Zerbi



Trans-duodenal ampullectomy (TDA) is a surgical option for the treatment of selected ampullary neoplasms. The aim of this study was to evaluate our experience with TDA for the treatment of ampullary neoplasms, focusing on indications, technical aspects, and short- and long-term outcomes.


All TDAs for ampullary neoplasms performed between January 2010 and December 2018 at our institution were retrospectively evaluated. Patients had ampullary neoplasms with low-grade dysplasia or in situ carcinoma (Tis) not suitable for an endoscopic approach, ampullary carcinoma unfit for pancreaticoduodenectomy (PD), or ampullary neuroendocrine G1-tumours.


Thirty-six patients were included in the study: 9 (25.0%) with neoplasms with low-grade dysplasia, 4 (11.1%) with G1 neuroendocrine tumours and 23 (63.9%) with Tis or invasive carcinoma. Mean operative time was 252.5 min. Overall and severe (Clavien–Dindo > IIIa) morbidity rate was 44.4% and 13.9%, respectively. No 90-day mortality was observed. At follow-up, no deaths were observed and local recurrence rate was 11.1% for patients with ampullary adenomas with low-grade dysplasia. Among four patients with neuroendocrine neoplasms, only one developed recurrence (pulmonary). Tis, T1 and T2 lesions were found in 16 (69.6%), 2 (8.7%) and 5 (21.7%) patients, respectively: recurrence occurred in 3 patients with Tis lesions (one malignant), no patients with T1 neoplasms and 2 patients with T2 lesions (3 patients had a survival of > 3 years).


TDA is a feasible and effective surgical procedure for the treatment of ampullary adenomas with low-grade dysplasia when endoscopic approach is contraindicated or has failed. For lesions with evidence of malignancy, TDA seems to be an oncological safe procedure for Tis ampullary cancer and a good palliative procedure for patients unfit for PD. Moreover, TDA may be appropriate for the treatment of G1 ampullary neuroendocrine neoplasms. A large multicentre study of TDA for early ampullary cancers is needed.


Trans-duodenal ampullectomy Surgical ampullectomy Ampullectomy Ampullary adenomas Early ampullary cancer Endoscopic ampullectomy 


Compliance with ethical standards


Gennaro Nappo, Damiano Gentile, Jacopo Galvanin, Giovanni Capretti, Cristina Ridolfi, Tommasangelo Petitti, Paola Spaggiari, Silvia Carrara, Francesca Gavazzi, Alessandro Repici and Alessandro Zerbi have nothing to disclose.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Gennaro Nappo
    • 1
    Email author
  • Damiano Gentile
    • 1
  • Jacopo Galvanin
    • 1
  • Giovanni Capretti
    • 1
  • Cristina Ridolfi
    • 1
  • Tommasangelo Petitti
    • 2
  • Paola Spaggiari
    • 3
  • Silvia Carrara
    • 4
  • Francesca Gavazzi
    • 1
  • Alessandro Repici
    • 4
    • 5
  • Alessandro Zerbi
    • 1
    • 5
  1. 1.Pancreatic Surgery UnitHumanitas Clinical and Research Center – IRCCSMilanItaly
  2. 2.Public Health and StatisticsCampus Bio-Medico University of RomeRomeItaly
  3. 3.Pathology DepartmentHumanitas Clinical and Research Center – IRCCSMilanItaly
  4. 4.Digestive Endoscopy Unit, Division of GastroenterologyHumanitas Clinical and Research Cancer Center – IRCCSMilanItaly
  5. 5.Humanitas UniversityMilanItaly

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