A low-residue diet before colonoscopy tends to improve tolerability by patients with no differences in preparation quality: a randomized trial

  • Elisa Gómez-Reyes
  • Alejandra Tepox-Padrón
  • Gregorio Cano-Manrique
  • Natalia J. Vilchis-Valadez
  • Stefany Mora-Bulnes
  • Gilberto Medrano-Duarte
  • Luis Gerardo Chaires-Garza
  • Guido Grajales-Figueroa
  • Daniel Ruiz-Romero
  • Félix I. Téllez-ÁvilaEmail author



The pre-colonoscopy diet traditionally involves 24 h of a clear liquid diet (CLD) in combination with a lavage solution; however, this preparation is poorly tolerated.


To compare the impact on the quality of bowel cleansing and tolerability of a CLD versus a low-residue diet (LRD).


We performed a randomized trial. Subjects were randomized to CLD or LRD the day before of elective colonoscopy. All subjects received a 4-L preparation of single-dose PEG beginning 16 h prior to colonoscopy. The Boston bowel preparation scale was used to evaluate bowel cleansing; an adequate-quality preparation was defined as a score ≥ 2 per segment.


A total of 205 subjects were included with a mean age (SD) of 55.6 (12.6) years; 133 (64.9%) of them were female. A total of 105 subjects were randomized to receive CLD and 100 to LRD. No significant differences in bowel preparation quality were observed between groups according to the section of colon: right colon (70% vs. 73%, p = 0.08), transverse colon (82% vs. 79%, p = 0.062), or left colon (80% vs. 78.7%, p = 0.28). There was a tendency toward less-frequent nausea (p = 0.08) and vomiting (p = 0.07) in patients with LRD. No differences between groups regarding ADR (12% vs. 10%) were noted.


An LRD before colonoscopy resulted in a tendency toward improved tolerability by patients, with no differences in the quality of bowel preparation.


Colonoscopy Diet Bowel cleansing Polyp Adenoma Colorectal cancer 


Author contributions

EG-R, GG-F, FIT-Á conception and design; EG-R, GG-F, FIT-Á, GCM, NJVV, SMB, analysis and interpretation of the data; FIT-Á, GM-D, AT-P: drafting of the article; FIT-Á and EG-R, FV-A: critical revision of the article for important intellectual content; EG-R, GCM, NJVV, SMB, GM-D, AT-P, LGC-G, GG-F, DR-R data collection; EG-R, GCM, NJVV, SMB, GM-D, AT-P, LGC-G, GG-F, DR-R, FV-A, Félix Ignacio T-A: final approval of the article.

Compliance with ethical standards


Elisa Gómez-Reyes, Alejandra Tepox-Padrón, Gregorio Cano Manrique, Natalia J. Vilchis Valadez, Stefany Mora Bulnes, GM-D, Luis Gerardo Chaires-Garza, Guido Grajales-Figueroa, Daniel Ruiz-Romero and Félix I. Téllez-Ávila have no conflicts of interest or financial ties to disclose.

Supplementary material

464_2019_7100_MOESM1_ESM.pdf (531 kb)
Supplementary material 1 (PDF 531 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Elisa Gómez-Reyes
    • 1
  • Alejandra Tepox-Padrón
    • 1
  • Gregorio Cano-Manrique
    • 1
  • Natalia J. Vilchis-Valadez
    • 1
  • Stefany Mora-Bulnes
    • 1
  • Gilberto Medrano-Duarte
    • 1
  • Luis Gerardo Chaires-Garza
    • 1
  • Guido Grajales-Figueroa
    • 1
  • Daniel Ruiz-Romero
    • 1
  • Félix I. Téllez-Ávila
    • 1
    Email author
  1. 1.Gastrointestinal Endoscopy Department of the National Institute of Medical Sciences and Nutrition Salvador ZubiranMexico CityMexico

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