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Long-term oncologic outcomes of laparoscopic versus open resection following stent insertion for obstructing colon cancer: a multi-center retrospective study

  • Sung Uk Bae
  • Chun-Seok Yang
  • Sohyun Kim
  • Dae Ro Lim
  • Woon Kyung Jeong
  • Dae Dong Kim
  • Jae Hwang Kim
  • Eung Jin Shin
  • Yoo Jin Lee
  • Ju Yup Lee
  • Nam Kyu Kim
  • Seong Kyu BaekEmail author
Article
  • 37 Downloads

Abstract

Background

This study compared oncologic outcomes between open and laparoscopic surgery following self-expanding metallic stents insertion for obstructing colon cancer.

Methods

This retrospective study included 50 patients who underwent open surgery and 44 patients who underwent laparoscopic surgery for obstructing left-sided colon cancer at four tertiary referral hospitals between June 2005 and December 2013.

Results

The median follow-up periods were 48 months and 47 months in the open and laparoscopic groups, respectively. The median operative time, time to soft diet, and length of stay were comparable between the groups. Four cases converted to open surgery (9.1%) in the laparoscopic group. The morbidity within 30 days after surgery was comparable between the groups (OR 0.931; 95% CI 0.357–2.426; p = 0.884). The proximal and distal resection margins, the histologic grade of tumor, TNM stage, median tumor size, and presence of lymphovascular invasion did not differ significantly between the groups. The 5-year overall survival (OS) rates of the open and laparoscopic groups were 67.1% and 71.7% (HR 1.028, 95% CI 0.491–2.15, p = 0.942) and the 5-year disease-free survival (DFS) rates were 55.8% and 61.5% (HR 0.982; 95% CI 0.522–1.847; p = 0.955), respectively. The recurrence pattern did not differ between the groups. Multivariate analysis showed that sex (p = 0.027), nodal stage (p = 0.043), and the proportion of patients receiving postoperative adjuvant chemotherapy (p = 0.002) were independent prognostic factors for OS. The proportion of patients receiving postoperative adjuvant chemotherapy (p = 0.017) was an independent prognostic factor for DFS.

Conclusions

Laparoscopic resection following stent insertion for obstructing colon cancer can be performed safely, with long-term oncologic outcomes comparable with those of open surgery.

Keywords

Colonic neoplasm Stent Laparoscopy Outcome 

Notes

Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MSIP) (No. 2014R1A5A2010008 and 2017R1C1B5076880). This work was supported by a grant from the Daegu-Gyeongbuk Surgical Society research foundation, Korea, 2018.

Compliance with ethical standards

Disclosures

Drs. Sung Uk Bae, Chun-Seok Yang, Sohyun Kim, Dae Ro Lim, Woon Kyung Jeong, Dae Dong Kim, Jae Hwang Kim, Eung Jin Shin, Yoo Jin Lee, Ju Yup Lee, Nam Kyu Kim, Seong Kyu Baek have no conflicts of interest or financial ties to disclose.

Ethical approval

IRB approval for this study across the multiple centers performed in accordance with the principles of the Declaration of Helsinki. The formal informed consent was waived.

Informed consent

The formal informed consent was waived.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Sung Uk Bae
    • 1
    • 2
  • Chun-Seok Yang
    • 3
  • Sohyun Kim
    • 4
  • Dae Ro Lim
    • 5
  • Woon Kyung Jeong
    • 1
  • Dae Dong Kim
    • 3
  • Jae Hwang Kim
    • 4
  • Eung Jin Shin
    • 5
  • Yoo Jin Lee
    • 6
  • Ju Yup Lee
    • 6
  • Nam Kyu Kim
    • 2
  • Seong Kyu Baek
    • 1
    Email author
  1. 1.Department of Surgery, School of MedicineKeimyung University and Dongsan Medical CenterDaeguRepublic of Korea
  2. 2.Division of Colorectal Surgery, Department of Surgery, Severance Hospital, Colorectal Cancer ClinicYonsei University College of MedicineSeoulRepublic of Korea
  3. 3.Department of Colorectal Surgery, School of MedicineCatholic University of DaeguGyeongsanRepublic of Korea
  4. 4.Department of Colorectal Surgery, College of MedicineYeungnam UniversityGyeongsanRepublic of Korea
  5. 5.Section of Colon and Rectal Surgery, Department of Surgery, Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheonRepublic of Korea
  6. 6.Division of Gastroenterology and Hepatology, Department of Internal MedicineKeimyung University School of MedicineDaeguRepublic of Korea

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