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Additive treatment improves survival in elderly patients after non-curative endoscopic resection for early gastric cancer

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Abstract

Background and study aims

Endoscopic resection (ER) is accepted as a curative treatment option for selected cases of early gastric cancer (EGC). Although additional surgery is often recommended for patients who have undergone non-curative ER, clinicians are cautious when managing elderly patients with GC because of comorbid conditions. The aim of the study was to investigate clinical outcomes in elderly patients following non-curative ER with and without additive treatment.

Patients and methods

Subjects included 365 patients (>75 years old) who were diagnosed with EGC and underwent ER between 2007 and 2015. Clinical outcomes of three patient groups [curative ER (n = 246), non-curative ER with additive treatment (n = 37), non-curative ER without additive treatment (n = 82)] were compared.

Results

Among the patients who underwent non-curative ER with additive treatment, 28 received surgery, three received a repeat ER, and six experienced argon plasma coagulation. Patients who underwent non-curative ER alone were significantly older than those who underwent additive treatment. Overall 5-year survival rates in the curative ER, non-curative ER with treatment, and non-curative ER without treatment groups were 84, 86, and 69 %, respectively. No significant difference in overall survival was found between patients in the curative ER and non-curative ER with additive treatment groups. The non-curative ER groups were categorized by lymph node metastasis risk factors to create a high-risk group that exhibited positive lymphovascular invasion or deep submucosal invasion greater than SM2 and a low-risk group without risk factors. Overall 5-year survival rate was lowest (60 %) in the high-risk group with non-curative ER and no additive treatment.

Conclusions

Elderly patients who underwent non-curative ER with additive treatment showed better survival outcome than those without treatment. Therefore, especially with LVI or deep submucosal invasion, additive treatment is recommended in patients undergoing non-curative ER, even if they are older than 75 years.

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Author information

Correspondence to Yong Chan Lee.

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Disclosures

Drs. Da Hyun Jung, Yong Chan Lee, Jie-Hyun Kim, Sang Kil Lee, Sung Kwan Shin, Jun Chul Park, Hyunsoo Chung, Jae Jun Park, Young Hoon Youn, and Hyojin Park have no conflicts of interest or financial ties to disclose.

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Jung, D., Lee, Y.C., Kim, J. et al. Additive treatment improves survival in elderly patients after non-curative endoscopic resection for early gastric cancer. Surg Endosc 31, 1376–1382 (2017). https://doi.org/10.1007/s00464-016-5123-3

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Keywords

  • Gastric cancer
  • Elderly patient
  • Endoscopic resection
  • Non-curative resection