Surgical Endoscopy

, Volume 31, Issue 2, pp 962–971 | Cite as

Robot-assisted laparoscopic versus open middle pancreatectomy: short-term results of a randomized controlled trial

  • Shi Chen
  • Qian Zhan
  • Jia-bin Jin
  • Zhi-chong Wu
  • Yuan Shi
  • Dong-feng Cheng
  • Hao Chen
  • Xia-xing Deng
  • Bai-yong ShenEmail author
  • Cheng-hong PengEmail author
  • Hong-wei Li
Dynamic Manuscript



This first prospective randomized controlled trial was performed to compare short-term outcomes of robot-assisted laparoscopic middle pancreatectomy (RA-MP) with open middle pancreatectomy (OMP).


RA-MP is a novel minimally invasive surgical technique for benign or borderline tumors in the pancreatic neck or body. Its short-term effectiveness and safety remain unknown, compared to OMP.


Patients eligible for MP from August 2011 to November 2015 were randomized into the RA-MP or OMP group. The primary endpoint was length of hospital stay (LOS). Secondary endpoints were intraoperative parameters, and postoperative and recovery variables.


A total of 100 patients were included into the study to analyze primary and secondary endpoints. Demographic characteristics and pathological parameters were similar in both groups. Furthermore, LOS was significantly shorter (15.6 vs. 21.7 days, P = 0.002), median operative time was reduced (160 vs. 193 min, P = 0.002), median blood loss was lower (50 vs. 200 mL, P < 0.001), rate of clinical postoperative pancreatic fistula (POPF) was lower (18 vs. 36.0 %, P = 0.043), nutritional status recovery was better, off-bed return to activity was expedited (3.1 vs. 4.6 days, P < 0.001), and resumption of bowel movement was faster (3.5 vs. 5.0 days, P < 0.001) in the RA-MP group, compared to the OMP group.


RA-MP was associated with significantly shorter LOS, reduced operative time, blood loss and clinical POPF rate, and expedited postoperative recovery, compared to OMP.


Middle pancreatectomy Robot-assisted laparoscopy Length of hospital stay Postoperative pancreatic fistula Randomized 



The authors thank all of the participating patients and their families, as well as investigators, research nurses, study coordinators, and operation staff. Shi Chen and Qian Zhan contributed equally to this work, and both should be considered as first author. Bai-yong Shen and Cheng-hong Peng also contributed equally, and both should be considered as co-corresponding author.

Compliance with ethical standards


Shi Chen, Qian Zhan, Jia-bin Jin, Zhi-chong Wu, Yuan Shi, Dong-feng Cheng, Hao Chen, Xia-xing Deng, Bai-yong Shen, Cheng-hong Peng, and Hong-wei Li have no conflicts of interest or financial ties to disclose.

Supplementary material

Supplementary material 1 (MP4 56045 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Shi Chen
    • 1
    • 2
  • Qian Zhan
    • 1
    • 3
  • Jia-bin Jin
    • 1
    • 3
  • Zhi-chong Wu
    • 1
    • 3
  • Yuan Shi
    • 1
    • 3
  • Dong-feng Cheng
    • 1
    • 3
  • Hao Chen
    • 1
    • 3
  • Xia-xing Deng
    • 1
    • 3
  • Bai-yong Shen
    • 1
    • 3
    Email author
  • Cheng-hong Peng
    • 1
    • 3
    Email author
  • Hong-wei Li
    • 1
    • 3
  1. 1.Department of General Surgery, Research Institute of Pancreatic DiseaseRuijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiPeople’s Republic of China
  2. 2.Department of Hepatobiliary Surgery, Fujian Provincial HospitalFujian Medical UniversityFuzhouPeople’s Republic of China
  3. 3.Shanghai Institute of Digestive SurgeryRuijin Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiPeople’s Republic of China

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