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Incidence, risk factors and consequences of bile leakage following laparoscopic major hepatectomy

Abstract

Background

Bile leakage (BL) remains a common cause of major morbidity after open major liver resection but has only been poorly described in patients undergoing laparoscopic major hepatectomy (LMH). The present study aimed to determine the incidence, risk factors and consequences of BL following LMH.

Methods

All 223 patients undergoing LMH between 2000 and 2013 at two tertiary referral centres were retrospectively analysed. BL was defined according to the International Study Group of Liver Surgery, and its incidence and consequences were assessed. Risk factors for BL were determined on multivariate analysis.

Results

BL occurred in 30 (13.5 %) patients, and its incidence remained stable over time (p = 0.200). BL was diagnosed following the presence of bile into the abdominal drain in 14 (46.7 %) patients and after drainage of symptomatic abdominal collections in 16 (53.3 %) patients without intra-operative drain placement. Grade A, B and C BL occurred in 3 (10.0 %), 23 (76.6 %) and 4 (13.4 %) cases, respectively. Interventional procedures for BL included endoscopic retrograde cholangiography, percutaneous and surgical drainage in 10 (33.3 %), 23 (76.7 %) and 4 (13.3 %) patients, respectively. BL was associated with significantly increased rates of symptomatic pleural effusion (30.0 vs. 11.4 %, p = 0.006), multiorgan failure (13.3 vs. 3.6 %, p = 0.022), postoperative death (10.0 vs. 1.6 %, p = 0.008) and prolonged hospital stay (18 vs. 8 days, p < 0.001). On multivariable analysis, BMI > 28 kg/m2 (OR 2.439, 95 % CI 1.878–2.771, p = 0.036), history of hepatectomy (OR 1.675, 95 % CI 1.256–2.035, p = 0.044) and biliary reconstruction (OR 1.975, 95 % CI 1.452–2.371, p = 0.039) were significantly associated with increased risk of BL.

Conclusions and relevance

After LMH, BL occurred in 13.5 % of the patients and was associated with significant morbidity. Patients with one or several risk factors for BL should benefit intra-operative drain placement.

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Author contributions

Study concept and design: Soubrane, Fuks, Cauchy, Gayet; Acquisition of data: Nomi, Schwarz, Belgaumkar, Fuks, Cauchy; Analysis and interpretation of data: Cauchy, Fuks, Gayet, Soubrane; Drafting of the manuscript: Cauchy, Fuks, Soubrane, Gayet; Critical revision of the manuscript: Fuks, Cauchy, Soubrane, Gayet, Scatton; Statistical analysis: Cauchy, Fuks, Study supervision: Soubrane, Fuks, Cauchy, Gayet.

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Correspondence to David Fuks.

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Disclosures

François Cauchy, David Fuks, Takeo Nomi, Lilian Schwarz, Ajay Belgaumkar, Olivier Scatton, Olivier Soubrane and Brice Gayet have no conflicts of interest or financial ties to disclose.

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Cauchy, F., Fuks, D., Nomi, T. et al. Incidence, risk factors and consequences of bile leakage following laparoscopic major hepatectomy. Surg Endosc 30, 3709–3719 (2016). https://doi.org/10.1007/s00464-015-4666-z

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Keywords

  • Bile leakage
  • Laparoscopic major hepatectomy
  • Postoperative complications
  • Abdominal drainage