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Prospective comparative study of the efficacy of staple-line reinforcement in laparoscopic sleeve gastrectomy



Staple-line reinforcement has been used with promising results in laparoscopic gastric bypass in order to reduce leakage, increase staple-line integrity, and diminish staple-site bleeding. The purpose of this study was to determine if staple-line reinforcement with bovine pericardial strips reduces surgical complications of laparoscopic sleeve gastrectomy (LSG).


This is a prospective comparative study of all patients who underwent LSG by a standard operative team in an 18-month period. Patients were enrolled in group A if they received staple-line reinforcement and in group B when not. The staple line was reinforced with bovine pericardium strips [Peri-Strips Dry® (PSD)].


In total, 187 patients, with a median preoperative BMI of 45.3 kg/m2 (range = 35.1–72.7), underwent LSG. Ninety-six patients were enrolled in group A and 91 in group B; the two groups were comparable in their various characteristics. Morbidity rate representing grade III–IV surgical complications reached 7.4% and mortality rate was 0.5%. Reinforcement with PSD significantly reduced the occurrence of bleeding from the staple line and intra-abdominal collections (P = 0.012 and 0.026). The leak rate was not significantly reduced in group A. Patients in group A required fewer days of hospitalization.


Reinforcement of the staple line in LSG resulted in significantly fewer surgical complications compared to standard stapling of the gastric tube. The additional cost due to the reinforcement of the staple line may be counterbalanced by the reduction in the length of hospitalization.

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Drs. Konstantinos M. Stamou, Evangelos Menenakos, Dimitris Dardamanis, Calliope Arabatzi, Leonidas Alevizos Konstantinos Albanopoulos, Emmanuel Leandros, and George Zografos have no conflicts of interest or financial ties to disclose.

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Correspondence to Konstantinos M. Stamou.

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Stamou, K.M., Menenakos, E., Dardamanis, D. et al. Prospective comparative study of the efficacy of staple-line reinforcement in laparoscopic sleeve gastrectomy. Surg Endosc 25, 3526–3530 (2011).

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  • LSG
  • Staple-line reinforcement
  • Complications