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Barrier methods used to prevent pelvic adhesions in videolaparoscopy: experimental study in female rabbits



This study was designed to evaluate the effectiveness of barrier methods to prevent adhesions in videolaparoscopy, comparing the use of Surgicel® and Interceed® with the control group.


We performed a controlled, randomized study in healthy adult female rabbits Oryctolagus cuniculu, inducing adhesions in the abdominal wall by resection of a peritoneal fragment and cauterization. In the control group, surgery was performed, and the other group was randomized to the use of the barrier method. After 21 days, videolaparoscopy was repeated, and the presence or absence of adhesions and their score were verified by performing biopsies of the surgical site in all groups.


No statistical differences were found in the results on adhesion formation and adhesions score among the three groups. In the control group, there were 54.5% cases of adhesion formation; the median score of adhesions was 6 (range, 3–10). In the Surgicel® group, there were 45.5% cases of adhesion formation; median score of adhesions was 6 (range, 4–10). In the Interceed® group, there were 45.5% cases of adhesion formation; median score of adhesions was 5 (range, 3–11).


No difference was found using barrier methods, Surgicel®, and Interceed® for preventing adhesion formation in videolaparoscopy.

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The project was funded by Fundo de Incentivo à Pesquisa e Eventos (FIPE) at HCPA.


Rosi P. Balbinotto, Ana L. Muller, André G. Nunes, Rodrigo Da Silva, Fabíola S. Meyer, Carlos S. Cerski and Manoel M. Trindade have no conflicts of interest or financial ties to disclose.

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Correspondence to Rosi P. Balbinotto.

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Balbinotto, R.P., Muller, A.L., Nunes, A.G. et al. Barrier methods used to prevent pelvic adhesions in videolaparoscopy: experimental study in female rabbits. Surg Endosc 25, 2637–2642 (2011). https://doi.org/10.1007/s00464-011-1617-1

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  • Adhesion prevention
  • Interceed®
  • Surgicel®