Surgical Endoscopy

, Volume 25, Issue 7, pp 2372–2377 | Cite as

A novel endoscopic fluorescent clip for the localization of gastrointestinal tumors

  • Yongdoo Choi
  • Kwang Gi Kim
  • Joa Kyum Kim
  • Kyoung Won Nam
  • Hyun Ho Kim
  • Dae Kyung SohnEmail author
New Technology



Accurate tumor localization is essential for gastrointestinal surgery, especially in cases of early cancer. This study was designed to develop a novel fluorescent clip for rapid and exact visualization of tumor sites.


A transparent polymer matrix containing highly bright fluorochromes was coated on the front end of endoscopic clips. The fluorescent clips were placed on the mucosal surface of a porcine colon and stomach, and the operator then attempted to identify the fluorescent clips from the outer serosal side of the colon and stomach. A 532-nm diode laser and filter glass were used for visualizing the fluorescence signals through the colonic tissue. A 650-nm diode laser and a digital charge-coupled device (CCD) camera equipped with a bandpass emission filter were used for the imaging of the fluorescent clips through the thick stomach tissue.


When a green light from a 532-nm diode laser (power density = 0.35 mW/cm2) was applied on the serosal surface of the porcine colon, we could identify all clips that had been placed endoscopically on the mucosal surface of the inner colonic wall. By using the light from a 650-nm diode laser (power density = 0.7 mW/cm2), we identified all fluorescent clips through the stomach wall in real time. Similar results were also obtained with the filtered xenon lamp.


An endoscopic fluorescent clip can be useful for the rapid and exact localization of tumors, and this technique can also be useful during laparoscopic surgery.


Endoscopic clip Fluorescence imaging Colorectal neoplasm Localization 



This study was supported by a grant from the National Cancer Center of Korea (NCC-1010060).


Drs. Y. D. Choi, K. G. Kim, J. K. Kim, K. W. Nam, H. H. Kim, and D. K. Sohn have no conflicts of interest or financial ties to disclose.

Supplementary material

Supplementary material 1 (AVI 9065 kb)


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yongdoo Choi
    • 1
  • Kwang Gi Kim
    • 2
  • Joa Kyum Kim
    • 1
  • Kyoung Won Nam
    • 2
  • Hyun Ho Kim
    • 2
  • Dae Kyung Sohn
    • 3
    Email author
  1. 1.Molecular Imaging and Therapy Branch, Research Institute and HospitalNational Cancer CenterGoyangKorea
  2. 2.Biomedical Engineering Branch, Research Institute and HospitalNational Cancer CenterGoyangKorea
  3. 3.Colorectal Cancer Branch, Research Institute and HospitalNational Cancer CenterGoyangRepublic of Korea

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