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Dysphagia

pp 1–5 | Cite as

Changes in the Excitability of Corticobulbar Projections Due to Intraoral Cooling with Ice

  • Michiyuki KawakamiEmail author
  • Sara Simeoni
  • Sara Tremblay
  • Ricci Hannah
  • Toshiyuki Fujiwara
  • John C. Rothwell
Original Article
  • 38 Downloads

Abstract

The aim of this study was to assess the effects of ice applied to the oral cavity on the excitability of corticobulbar projections to the swallowing muscles. The subjects were 8 healthy adult volunteers (mean age 29.0 ± 4.9 years). Motor-evoked potentials (MEPs) were recorded from the suprahyoid muscle complex using surface electrodes. Two blocks of 20 MEPs with a test stimulus intensity of 120% of the resting motor threshold were recorded at rest (baseline). Subjects then underwent 5-min thermal stimulation by either of 3 different types: (1) “ice-stick inside mouth,” (2) “ice-stick on neck,” and (3) “room temperature inside mouth.” Blocks of 20 MEPs were then recorded immediately and at 5-min intervals for the following 15 min. There was a significant difference in the effects of the 3 interventions on the amplitude of the MEPs following stimulation (two-way ANOVA: INTERVENTION × TIME; F8,84 = 3.76, p < 0.01). One-way ANOVA was used to evaluate the changes over time for each intervention type. Only “ice-stick inside mouth” caused an increase in the MEPs (one-way ANOVA main effect of TIME: F4,28 = 4.04, p = 0.010) with significant differences between baseline and P10 (mean difference 0.050; confidence interval (CI) 95% 0.019–0.079; p = 0.004). There were no significant effects of either “ice-stick on neck” or “room temperature inside mouth” (F4,28 = 1.13, p = 0.36; F4,28 = 1.36, p = 0.27, respectively). Ice stimulation within the oral cavity increases the excitability of the cortical swallowing motor pathway.

Keywords

Swallowing Temperature Reaction time task Motor-evoked potential Deglutition Deglutition disorders 

Notes

Author Contribution

MK and JCR contributed to the conception and study design, data acquisition, analysis and interpretation, and drafting of the manuscript. SS and RH contributed to data acquisition and analysis. ST and TF contributed to data acquisition, analysis and drafting of the manuscript. All authors revised the article critically and approved the final version for publication.

Compliance with Ethical Standards

Disclosure

JCR and RH were supported by a Medical Research Council Grant (MR/K01384X/1). The other authors declare no conflicts of interest.

Informed Consent

Informed consent was obtained from all participants.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Sobell Department of Motor Neuroscience and Movement DisordersUCL Institute of NeurologyLondonUK
  2. 2.Department of Rehabilitation MedicineKeio University School of MedicineTokyoJapan
  3. 3.Department of Physical Medicine and RehabilitationJuntendo University Graduate School of MedicineTokyoJapan

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