Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Performance of a two-stage fermentor with cell recycle for continuous production of lactic acid

Abstract

The performasnce of a recycle two-stage fermentor with cell separators after each stage is analyzed numerically for continuous production of lactic acid. In this system, the bleed broth withdrawn from the first stage is provided to the second fermentor to reuse viable cells in the bleed. Biological rate expressions and parametric values are taken from the literature. The effects of operating parameters on the concentrations of total and viable cells, substrate and product in each stage, the lactic acid productivity and the substrate conversion are examined and discussed. With respect to overall productivity and conversion, it is found that the present fermentor system is more efficient than a conventional chemostat fermentor with cell recycle.

This is a preview of subscription content, log in to check access.

Author information

Additional information

Received: 18 November 1998

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nishiwaki, A., Dunn, I. Performance of a two-stage fermentor with cell recycle for continuous production of lactic acid. Bioprocess Engineering 21, 299–305 (1999). https://doi.org/10.1007/s004490050679

Download citation

Keywords

  • Viable Cell
  • Lactic Acid
  • Acid Productivity
  • Operating Parameter
  • Rate Expression