The performasnce of a recycle two-stage fermentor with cell separators after each stage is analyzed numerically for continuous production of lactic acid. In this system, the bleed broth withdrawn from the first stage is provided to the second fermentor to reuse viable cells in the bleed. Biological rate expressions and parametric values are taken from the literature. The effects of operating parameters on the concentrations of total and viable cells, substrate and product in each stage, the lactic acid productivity and the substrate conversion are examined and discussed. With respect to overall productivity and conversion, it is found that the present fermentor system is more efficient than a conventional chemostat fermentor with cell recycle.
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Received: 18 November 1998
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Nishiwaki, A., Dunn, I. Performance of a two-stage fermentor with cell recycle for continuous production of lactic acid. Bioprocess Engineering 21, 299–305 (1999). https://doi.org/10.1007/s004490050679
- Viable Cell
- Lactic Acid
- Acid Productivity
- Operating Parameter
- Rate Expression