Bioprocess and Biosystems Engineering

, Volume 42, Issue 11, pp 1769–1777 | Cite as

Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticles

  • Muthu Thiruvengadam
  • Ill-Min Chung
  • Thandapani Gomathi
  • Mohammad Azam Ansari
  • Venkatesan Gopiesh Khanna
  • Vaishnavi Babu
  • Govindasamy RajakumarEmail author
Research Paper


The phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower Millettia pinnata, and their corresponding characteristics were studied using UV–visible spectroscopy, XRD, FT-IR, SEM, TEM, and SAED analysis. Copper acetate was reduced to copper nanoparticles and is confirmed by UV–visible spectrophotometer analysis. The maximum absorption occurring at 384 nm at the visible spectrum of UV rays confirms the surface plasmon resonance of the nanoparticles. The result of the FTIR spectroscopy analysis of the nanoparticles complements the involvement of organic mioties of the flower extract in the synthesis. The synthesized particles were extremely durable, spherical with the average particle size in the range of 23 ± 1.10 nm. The Cu-NPs exhibited greater inhibition on DPPH radical and nitric oxide scavenging activities. The biologically synthesized Cu-NPs was receptive to the Gram-negative and Gram-positive bacteria as well. The Cu-NPs exhibited strong anti-inflammatory activity using albumin denaturation and membrane stabilization. The present study is the first effort done to synthesize of Cu-NPs from the extract of M. pinnata flower. Consequently, to authenticate the results and to establish the antioxidant, antibacterial, an anti-diabetic and anti-inflammatory agent, in vivo studies are made in the molecular level.


Millettia pinnata Green chemistry method Copper nanoparticles Characterization Pharmaceutical activities 



This paper was supported by the KU-Research Professor Program of Konkuk University, Seoul, South Korea.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Muthu Thiruvengadam
    • 1
  • Ill-Min Chung
    • 2
  • Thandapani Gomathi
    • 3
  • Mohammad Azam Ansari
    • 4
  • Venkatesan Gopiesh Khanna
    • 5
  • Vaishnavi Babu
    • 6
  • Govindasamy Rajakumar
    • 1
    Email author
  1. 1.Department of Applied Bioscience, College of Life and Environmental SciencesKonkuk UniversitySeoulSouth Korea
  2. 2.Department of Crop Science, College of Sanghur Life ScienceKonkuk UniversitySeoulSouth Korea
  3. 3.Department of ChemistryD.K.M. College for WomenVelloreIndia
  4. 4.Department of Epidemic Disease Research, Institute of Research and Medical Consultations (IRMC)Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia
  5. 5.Department of BiotechnologyVels Institute of Science, Technology & Advanced StudiesChennaiIndia
  6. 6.Quality Control in MicrobiologyKemwell Biopharma Pvt. LtdBangaloreIndia

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