Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Non-toxic nanoparticles from phytochemicals: preparation and biomedical application

  • 1147 Accesses

  • 21 Citations

Abstract

Nanoparticles (NPs) have various applications in biomedicine and drug delivery carriers and also are widely used in cosmetics. However, the preparation of biocompatible and non-toxic nanomaterials is a very important issue as most of the starting materials are synthesized using toxic chemical reagents. This review introduces the preparation of biocompatible NPs in a range of their concentrations using phytochemicals for biomedicine and biotechnology. Phytochemicals are natural products that are extracted from plants, vegetables, and fruits. Phytochemicals serve as reducing agents and stabilizers during NP synthesis to convert metal ions to metal NPs in water. Possible applications of such nanomaterials in biomedical sciences are also described in this review.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

References

  1. 1.

    Zhang L, Luo Q, Zhang F, Zhang DM, Wang YS, Sun YL, Dong WF, Liu JQ, Huo QS, Sun HB (2012) High-performance magnetic antimicrobial Janus nanorods decorated with Ag nanoparticles. J Mater Chemistry 22:23741–23744

  2. 2.

    Chung YC, Chen IH, Chen CJ (2008) The surface modification of silver nanoparticles by phosphoryl disulfides for improved biocompatibility and intracellular uptake. Biomaterials 29:1807–1816

  3. 3.

    Cabada TF, de Pablo CSL, Serrano AM, Guerrero FD, Olmedo JJS, Gomez MR (2012) Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods. Int J Nanomed 7:1511–1523

  4. 4.

    Tong L, Wei QS, Wei A, Cheng JX (2009) Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects. Photochem Photobiol 85:21–32

  5. 5.

    Chen CL, Kuo LR, Lee SY, Hwu YK, Chou SW, Chen CC, Chang FH, Lin KH, Tsai DH, Chen YY (2013) Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles. Biomaterials 34:1128–1134

  6. 6.

    Lee JH, Jang JT, Choi JS, Moon SH, Noh SH, Kim JW, Kim JG, Kim IS, Park KI, Cheon J (2011) Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat Nanotechnol 6:418–422

  7. 7.

    Kim EH, Ahn Y, Lee HS (2007) Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan. J Alloy Compd 434:633–636

  8. 8.

    Lee JH, Huh YM, Jun Y, Seo J, Jang J, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13:95–99

  9. 9.

    Shan Z, Wu Q, Wang XX, Zhou ZW, Oakes KD, Zhang X, Huang QM, Yang WS (2010) Bacteria capture, lysate clearance, and plasmid DNA extraction using pH-sensitive multifunctional magnetic nanoparticles. Anal Biochem 398:120–122

  10. 10.

    Liang Y, Gong JL, Huang Y, Zheng Y, Jiang JH, Shen GL, Yu RQ (2007) Biocompatible core-shell nanoparticle-based surface-enhanced Raman scattering probes for detection of DNA related to HIV gene using silica-coated magnetic nanoparticles as separation tools. Talanta 72:443–449

  11. 11.

    Haque M, Im H-Y, Seo J-E, Hasan M, Woo K, Kwon O-S (2013) Acute toxicity and tissue distribution of CdSe/CdS-MPA quantum dots after repeated intraperitoneal injection to mice. J Appl Toxicol 33:940–950

  12. 12.

    Lewinski N, Colvin V, Drezek R (2008) Cytotoxicity of nanoparticles. Small 4:26–49

  13. 13.

    Tang Y, Han S, Liu H, Chen X, Huang L, Li X, Zhang J (2013) The role of surface chemistry in determining in vivo biodistribution and toxicity of CdSe/ZnS core-shell quantum dots. Biomaterials 34:8741–8755

  14. 14.

    Levard C, Hotze EM, Lowry GV, Brown GE (2012) Environmental transformations of silver nanoparticles: impact on stability and toxicity. Environ Sci Technol 46:6900–6914

  15. 15.

    Kim S, Ryu DY (2013) Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues. J Appl Toxicol 33:78–89

  16. 16.

    Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T (2010) Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons. Neuroscience 166:292–304

  17. 17.

    Radi R, Beckman JS, Bush KM, Freeman BA (1991) Peroxynitrite oxidation of sulfhydryls - the cytotoxic potential of superoxide and nitric-oxide. J Biol Chem 266:4244–4250

  18. 18.

    Wickramasinghe SN, Gardner B, Barden G (1987) Circulating cytotoxic protein generated after ethanol-consumption—identification and mechanism of reaction with cells. Lancet 2:122–126

  19. 19.

    Hone DC, Walker PI, Evans-Gowing R, FitzGerald S, Beeby A, Chambrier I, Cook MJ, Russell DA (2002) Generation of cytotoxic singlet oxygen via phthalocyanine-stabilized gold nanoparticles: a potential delivery vehicle for photodynamic therapy. Langmuir 18:2985–2987

  20. 20.

    Bellik Y, Boukraa L, Alzahrani HA, Bakhotmah BA, Abdellah F, Hammoudi SM, Iguer-Ouada M (2013) Molecular mechanism underlying anti-inflammatory and anti-allergic activities of phytochemicals: an update. Molecules 18:322–353

  21. 21.

    Seifried HE, Anderson DE, Fisher EI, Milner JA (2007) A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 18:567–579

  22. 22.

    Vinod BS, Maliekal TT, Anto RJ (2013) Phytochemicals as chemosensitizers: from molecular mechanism to clinical significance. Antioxid Redox Signal 18:1307–1348

  23. 23.

    Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768–780

  24. 24.

    RiceEvans CA, Miller NJ, Paganga G (1996) Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol Med 20:933–956

  25. 25.

    Amaral S, Mira L, Nogueira JMF, da Silva AP, Florencio MH (2009) Plant extracts with anti-inflammatory properties-A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships. Bioorg Med Chem 17:1876–1883

  26. 26.

    Modak B, Contreras ML, Gonzalez-Nilo F, Torres R (2005) Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum. Bioorg Med Chem Lett 15:309–312

  27. 27.

    Silva MM, Santos MR, Caroco G, Rocha R, Justino G, Mira L (2002) Structure-antioxidant activity relationships of flavonoids: a re-examination. Free Radical Res 36:1219–1227

  28. 28.

    Nune SK, Chanda N, Shukla R, Katti K, Kulkarni RR, Thilakavathy S, Mekapothula S, Kannan R, Katti KV (2009) Green nanotechnology from tea: phytochemicals in tea as building blocks for production of biocompatible gold nanoparticles. J Mater Chem 19:2912–2920

  29. 29.

    Zhang L, Yu FQ, Cole AJ, Chertok B, David AE, Wang JK, Yang VC (2009) Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. Aaps J 11:693–699

  30. 30.

    Dhar S, Reddy EM, Shiras A, Pokharkar V, Prasad BLV (2008) Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations. Chem-A Eur J 14:10244–10250

  31. 31.

    Park JH, Choi TB, Kim SW, Hur MG, Yang SD, Yu KH (2009) A study on effective extraction of isoflavones from soy germ using the electron beam. Radiat Phys Chem 78:623–625

  32. 32.

    Lin CY, Huang CS, Huang CY, Yin MC (2009) Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice. J Agric Food Chem 57:6661–6667

  33. 33.

    Aruoma OI, Murcia A, Butler J, Halliwell B (1993) Evaluation of the antioxidant and prooxidant actions of gallic acid and its derivatives. J Agric Food Chem 41:1880–1885

  34. 34.

    Yilmaz Y, Toledo RT (2004) Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem 52:255–260

  35. 35.

    Shukla R, Nune SK, Chanda N, Katti K, Mekapothula S, Kulkami RR, Welshons WV, Kannan R, Katti KV (2008) Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanopartictes. Small 4:1425–1436

  36. 36.

    Lee J, Kim HY, Zhou H, Hwang S, Koh K, Han DW, Lee J (2011) Green synthesis of phytochemical-stabilized Au nanoparticles under ambient conditions and their biocompatibility and antioxidative activity. J Mater Chem 21:13316–13326

  37. 37.

    Lee J, Koh K, Hwang S (2012) Density functional theoretical study on the reduction potentials of catechols in water. Bull Korean Chem Soc 33:3889–3890

  38. 38.

    Arunachalam KD, Annamalai SK, Hari S (2013) One-step green synthesis and characterization of leaf extract-mediated biocompatible silver and gold nanoparticles from Memecylon umbellatum. Int J Nanomed 8:1307–1315

  39. 39.

    Ramamurthy C, Sampath KS, Arunkumar P, Kumar MS, Sujatha V, Premkumar K, Thirunavukkarasu C (2013) Green synthesis and characterization of selenium nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells. Bioprocess Biosyst Eng 36:1131–1139

  40. 40.

    Sahu N, Soni D, Chandrashekhar B, Sarangi BK, Satpute D, Pandey RA (2013) Synthesis and characterization of silver nanoparticles using Cynodon dactylon leaves and assessment of their antibacterial activity. Bioprocess Biosyst Eng 36:999–1004

  41. 41.

    Kim D, Park S, Lee JH, Jeong YY, Jon S (2007) Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging. J Am Chem Soc 129:7661–7665

  42. 42.

    Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM (2006) Gold nanoparticles: a new X-ray contrast agent. Br J Radiol 79:248–253

  43. 43.

    Kattumuri V, Katti K, Bhaskaran S, Boote EJ, Casteel SW, Fent GM, Robertson DJ, Chandrasekhar M, Kannan R, Katti KV (2007) Gum arabic as a phytochemical construct for the stabilization of gold nanoparticles: in vivo pharmacokinetics and X-ray-contrast-imaging studies. Small 3:333–341

  44. 44.

    Chanda N, Shukla R, Zambre A, Mekapothula S, Kulkarni RR, Katti K, Bhattacharyya K, Fent GM, Casteel SW, Boote EJ, Viator JA, Upendran A, Kannan R, Katti KV (2011) An Effective strategy for the synthesis of biocompatible gold nanoparticles using cinnamon phytochemicals for phantom CT imaging and photoacoustic detection of cancerous cells. Pharm Res 28:279–291

Download references

Acknowledgments

This research was supported by the Korea Healthcare Technology Research & Development Project, Ministry of Health & Welfare, Republic of Korea (A110191-1202-0000200) and was also supported by the Financial Supporting Project of Long-term Overseas Dispatch of PNU’s Tenure-track Faculty.

Author information

Correspondence to Jaebeom Lee.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, J., Park, E.Y. & Lee, J. Non-toxic nanoparticles from phytochemicals: preparation and biomedical application. Bioprocess Biosyst Eng 37, 983–989 (2014). https://doi.org/10.1007/s00449-013-1091-3

Download citation

Keywords

  • Biocompatible nanoparticle
  • Biomedical application
  • Non-toxic
  • Phytochemicals